ArticlePloS one2021
Plasmid analysis of NDM metallo-β-lactamase-producing Enterobacterales isolated in Vietnam.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 25 citations in OpenAlex.
- Dynamics of a large multidrug-resistant plasmid encoding New Delhi metallo-β-lactamase-1 and oxacillinase-58 carbapenemases inMicrobial genomics · 2026Article
- Tracking ESBL-ProducingVeterinary sciences · 2026Article
- Genetic features of blaBMC microbiology · 2025Article
- Emergence of carbapenem-resistantMicrobiology spectrum · 2025Article
- Genomic characterization of multidrug-resistantFrontiers in microbiology · 2025Article
- Emergence of NDM-1 on IncR-IncFIA (HI1) plasmid in carbapenem-resistantFrontiers in microbiology · 2025Article
- Genomic investigation of multispecies and multivariantInfection control and hospital epidemiology · 2024Article
- Trends in carbapenem resistance in Pre-COVID and COVID times in a tertiary care hospital in North India.Annals of clinical microbiology and antimicrobials · 2023Article
- Large-scale analysis of putative plasmids in clinical multidrug-resistantFrontiers in microbiology · 2023Article
- Genomic Epidemiological Analysis of Antimicrobial-Resistant Bacteria with Nanopore Sequencing.Methods in molecular biology (Clifton, N.J.) · 2023Article
- [Plasmids carried by carbapenems-resistantZhonghua shao shang yu chuang mian xiu fu za zhi · 2022Observational
- Ecological dynamics of plasmid transfer and persistence in microbial communities.Current opinion in microbiology · 2022Review
- Detection of IMP-4 and SFO-1 co-producing ST51Frontiers in cellular and infection microbiology · 2022Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carbapenem-resistant Enterobacterales (CRE) represent a serious threat to public health due to the lack of treatment and high mortality. The rate of antimicrobial resistance of Enterobacterales isolates to major antimicrobials, including carbapenems, is much higher in Vietnam than in Western countries, but the reasons remain unknown due to the lack of genomic epidemiology research. A previous study suggested that carbapenem resistance genes, such as the carbapenemase gene blaNDM, spread via plasmids among Enterobacterales in Vietnam. In this study, we characterized blaNDM-carrying plasmids in Enterobacterales isolated in Vietnam, and identified several possible cases of horizontal transfer of plasmids both within and among species of bacteria. Twenty-five carbapenem-nonsusceptible isolates from a medical institution in Hanoi were sequenced on Illumina short-read sequencers, and 13 blaNDM-positive isolates, including isolates of Klebsiella pneumoniae, Escherichia coli, Citrobacter freundii, Morganella morganii, and Proteus mirabilis, were further sequenced on an Oxford Nanopore Technologies long-read sequencer to obtain complete plasmid sequences. Almost identical 73 kb IncFII(pSE11)::IncN hybrid plasmids carrying blaNDM-1 were found in a P. mirabilis isolate and an M. morganii isolate. A 112 kb IncFII(pRSB107)::IncN hybrid plasmid carrying blaNDM-1 in an E. coli isolate had partially identical sequences with a 39 kb IncR plasmid carrying blaNDM-1 and an 88 kb IncFII(pHN7A8)::IncN hybrid plasmid in a C. freundii isolate. 148-149 kb IncFIA(Hl1)::IncA/C2 plasmids and 75-76 kb IncFII(Yp) plasmids, both carrying blaNDM-1 were shared among three sequence type 11 (ST11) isolates and three ST395 isolates of K. pneumoniae, respectively. Most of the plasmids co-carried genes conferring resistance to clinically relevant antimicrobials, including third-generation cephalosporins, aminoglycosides, and fluoroquinolones, in addition to blaNDM-1. These results provide insight into the genetic basis of CRE in Vietnam, and could help control nosocomial infections.
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