Evidence map›Paper›PMID 34319859›Full record

ArticleXenobiotica; the fate of foreign compounds in biological systems2021

Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity.

Dongxue Sun, Xiaoxia Gao, Qiao Wang, Kristopher W Krausz, Zhongze Fang, Youbo Zhang, Cen Xie, Frank J Gonzalez

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Xenobiotica; the fate of foreign compounds in biological systems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Crosstalk between CYP2E1 and PPARActa pharmaceutica Sinica. B · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Dongxue SunCollege of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, Liaoning, P. R. China.
Xiaoxia GaoLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Qiao WangSchool of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei, P. R. China.
Kristopher W KrauszLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Zhongze FangLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Youbo ZhangLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Cen XieLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Frank J GonzalezLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
National Institutes of Health · USCenter for Cancer Research · USChinese Academy of Sciences · CNHebei Medical University · CNShenyang Pharmaceutical University · CN

Funding

Xenobiotic-Metabolizing EnzymesZ01BC005562 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GONZALEZ, FRANK J · 1996 to 2008
$1.3M
Intramural NIH HHS Z01 BC005562
6 · The paper itself

Abstract

Podophyllotoxin (POD) is a natural compound with antiviral and anticancer activities. The purpose of the present study was to determine the metabolic map of POD

Indexed as

Chemical and Drug Induced Liver InjuryTandem Mass SpectrometryAnimalsAntiviral AgentsChromatography, High Pressure LiquidMiceMicrosomes, LiverPodophyllotoxinAntiviral AgentsPodophyllotoxinCYPhepatic and intestinal toxicityliver microsomespodophyllotoxin metabolismrecombinant drug-metabolizing enzymes

Identifiers

PMID34319859
PMCPMC9491014
OpenAlexW3186571269

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.