Evidence map›Paper›PMID 34319857›Full record

ArticleAmerican journal of respiratory and critical care medicine2021

Virus-induced Volatile Organic Compounds Are Detectable in Exhaled Breath during Pulmonary Infection.

Faisal Kamal, Sacheen Kumar, Michael R Edwards, Kirill Veselkov, Ilaria Belluomo, Tatiana Kebadze, Andrea Romano, Maria-Belen Trujillo-Torralbo, Tasnim Shahridan Faiez, Ross Walton and 8 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06453993 (Temporal Variation in Exhaled Volatile Organic Compounds in Response to Therapeutic Intervention in Esophageal Cancer Patients), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06453993 nacompletednot on this map

Temporal Variation in Exhaled Volatile Organic Compounds in Response to Therapeutic Intervention in Esophageal Cancer Patients

TypeinterventionalSponsorBenaroya Research InstituteRan2019 to 2023Enrolled46ConditionsEsophageal CancerArmsExhaled VOC breath test
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. CyranoseVeterinary sciences · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Defining VOC signatures of airway epithelial cells with PM2.5 exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Article
  11. Observational
  12. Review
  13. Review
  14. Review
  15. Article
  16. Volatilomes of human infection.Analytical and bioanalytical chemistry · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Faisal KamalDepartment of Surgery and Cancer.
Sacheen KumarDepartment of Surgery and Cancer.ORCID 0000-0002-4692-4554
Michael R EdwardsNational Heart and Lung Institute, and.
Kirill VeselkovDepartment of Surgery and Cancer.
Ilaria BelluomoDepartment of Surgery and Cancer.
Tatiana KebadzeNational Heart and Lung Institute, and.
Andrea RomanoDepartment of Surgery and Cancer.
Maria-Belen Trujillo-TorralboNational Heart and Lung Institute, and.
Tasnim Shahridan FaiezCentre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom; and.
Ross WaltonNational Heart and Lung Institute, and.
Andrew I RitchieNational Heart and Lung Institute, and.
Dexter J WisemanNational Heart and Lung Institute, and.ORCID 0000-0002-6398-7450
Ivan LaponogovDepartment of Surgery and Cancer.
Gavin DonaldsonNational Heart and Lung Institute, and.
Jadwiga A WedzichaNational Heart and Lung Institute, and.
Sebastian L JohnstonNational Heart and Lung Institute, and.
Aran SinganayagamCentre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom; and.ORCID 0000-0001-9849-0033
George B HannaDepartment of Surgery and Cancer.ORCID 0000-0003-2897-0140
Lung Institute · USImperial College London · GBNational Health Service · GB

Funding

Department of HealthMedical Research Council MR/V000098/1Wellcome TrustWellcome Trust 215275/Z/19/Z
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Early DiagnosisAdultAgedAged, 80 and overBiomarkersBreath TestsFemaleHumansMaleMiddle AgedPicornaviridae InfectionsPulmonary Disease, Chronic ObstructiveVolatile Organic CompoundsBiomarkersVolatile Organic Compoundschronic obstructive pulmonary diseaserhinovirusviral infectionvolatile organic compound

Identifiers

PMID34319857
PMCPMC8663017
OpenAlexW3184479160

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.