ArticleACS infectious diseases2021
Reproducible Breath Metabolite Changes in Children with SARS-CoV-2 Infection.
Article in ACS infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- A comprehensive meta-analysis and systematic review of breath analysis in detection of COVID-19 through Volatile organic compounds.Diagnostic microbiology and infectious disease · 2024Pooled it
- The potential of volatile organic compounds-based breath analysis for COVID-19 screening: a systematic review & meta-analysis.Diagnostic microbiology and infectious disease · 2022Pooled it
- Trained Scent Dog Detection and GC-MS Analysis of Volatile Organic Compounds from Murine Coronavirus-Infected Cell Cultures.Animals : an open access journal from MDPI · 2026Article
- Nanobiosensors: A Potential Tool to Decipher the Nexus Between SARS-CoV-2 Infection and Gut Dysbiosis.Sensors (Basel, Switzerland) · 2026Review
- Molecular profiling of exhaled breath condensate in respiratory diseases.Annals of medicine · 2025Review
- Detection of Lung Cancer Biomarkers CACS omega · 2025Article
- Article
- Tile-Based Fisher Ratio Analysis with Support Vector Machine Regression Modeling of GC×GC-TOFMS Data of VOCs Produced byAnalytical chemistry · 2025Article
- A Comprehensive Review of Biomarker Sensors for a Breathalyzer Platform.Sensors (Basel, Switzerland) · 2024Review
- Luminescence Probes in Bio-Applications: From Principle to Practice.Biosensors · 2024Review
- Progress and challenges of developing volatile metabolites from exhaled breath as a biomarker platform.Metabolomics : Official journal of the Metabolomic Society · 2024Review
- Detection of COVID-19 by quantitative analysis of carbonyl compounds in exhaled breath.Scientific reports · 2024Article
- The science behind the nose: correlating volatile organic compound characterisation with canine biodetection of COVID-19.ERJ open research · 2024Article
- Breath metabolomics for diagnosis of acute respiratory distress syndrome.Critical care (London, England) · 2024Observational
- Tuning phosphorene and MoSRSC advances · 2024Article
- Volatilomes of human infection.Analytical and bioanalytical chemistry · 2024Review
- A feasibility study on exhaled breath analysis using UV spectroscopy to detect COVID-19.Journal of breath research · 2023Article
- Enhanced real-time mass spectrometry breath analysis for the diagnosis of COVID-19.ERJ open research · 2023Article
- iOBPdb A Database for Experimentally Determined Functional Characterization of Insect Odorant Binding Proteins.Scientific data · 2023Article
- Comprehensive Two-Dimensional Gas Chromatography as a Bioanalytical Platform for Drug Discovery and Analysis.Pharmaceutics · 2023Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
SARS-CoV-2 infection is diagnosed through detection of specific viral nucleic acid or antigens from respiratory samples. These techniques are relatively expensive, slow, and susceptible to false-negative results. A rapid noninvasive method to detect infection would be highly advantageous. Compelling evidence from canine biosensors and studies of adults with COVID-19 suggests that infection reproducibly alters human volatile organic compound (VOC) profiles. To determine whether pediatric infection is associated with VOC changes, we enrolled SARS-CoV-2 infected and uninfected children admitted to a major pediatric academic medical center. Breath samples were collected from children and analyzed through state-of-the-art GCxGC-ToFMS. Isolated features included 84 targeted VOCs. Candidate biomarkers that were correlated with infection status were subsequently validated in a second, independent cohort of children. We thus find that six volatile organic compounds are significantly and reproducibly increased in the breath of SARS-CoV-2 infected children. Three aldehydes (octanal, nonanal, and heptanal) drew special attention, as aldehydes are also elevated in the breath of adults with COVID-19. Together, these biomarkers demonstrate high accuracy for distinguishing pediatric SARS-CoV-2 infection and support the ongoing development of novel breath-based diagnostics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.