Evidence map›Paper›PMID 34319569›Full record

ArticleInfection2021

Long COVID, a comprehensive systematic scoping review.

Hossein Akbarialiabad, Mohammad Hossein Taghrir, Ashkan Abdollahi, Nasrollah Ghahramani, Manasi Kumar, Shahram Paydar, Babak Razani, John Mwangi, Ali A Asadi-Pooya, Leila Malekmakan and 1 more

Open access · bronzeAbstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 187 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
187citing papers in PubMed, 12 pooled it
32.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

187 citing papers in PubMed, 12 syntheses or guidelines pooled it, 353 citations in OpenAlex.

  1. Pooled it
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  5. Pathophysiological Mechanisms in Long COVID: A Mixed Method Systematic Review.International journal of environmental research and public health · 2024
    Pooled it
  6. Pooled it
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  8. SARS-CoV-2 post-acute sequelae in previously hospitalised patients: systematic literature review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023
    Pooled it
  9. Post-COVID-19 dyspnoea and pulmonary imaging: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023
    Pooled it
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  13. Trial
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  18. Review
  19. Impact of nutrition on long COVID.Sports medicine and health science · 2026
    Review
  20. Article

127 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

Hossein Akbarialiabad *Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammad Hossein Taghrir *Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Ashkan AbdollahiShiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Nasrollah GhahramaniDivision of Nephrology, Department of Medicine, Penn State University College of Medicine, Hershey, PA, 17033, USA.
Manasi KumarDepartment of Psychiatry, University of Nairobi, Nairobi, Kenya.
Shahram PaydarTrauma Research Center, Shahid Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Babak RazaniCardiology Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA.
John MwangiPulmonary and Critical Care Medicine, Saint Louis University School of Medicine, Saint Louis, MO, USA.
Ali A Asadi-PooyaEpilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Leila MalekmakanShiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Bahar BastaniProfessor of Medicine-Nephrology, Saint Louis University School of Medicine, Saint Louis, MO, USA. bahar.bastani@health.slu.edu.ORCID http://orcid.org/0000-0002-2138-4248
Shiraz University of Medical Sciences · IRSaint Louis University · USPennsylvania State University · USThomas Jefferson University · USUniversity of Nairobi · KEWashington University in St. Louis · US

Funding

Mapping impact and developing mitigation strategies for climate change-mental health nexus in the context of vulnerable adolescent populations in KenyaK43TW010716 · FIC · UNIVERSITY OF NAIROBI · PI KUMAR, MANASI · 2018 to 2022
$648k
FIC NIH HHS K43 TW010716
6 · The paper itself

Abstract

purposeTo find out what is known from literature about Long COVID until January 30, 2021.

methodsWe undertook a four-step search with no language restriction. A preliminary search was made to identify the keywords. A search strategy of all electronic databases resulted in 66 eligible studies. A forward and backward search of the references and citations resulted in additional 54 publications. Non-English language articles were translated using Google Translate. We conducted our scoping review based on the PRISMA-ScR Checklist.

resultsOf 120 papers, we found only one randomized clinical trial. Of the 67 original studies, 22 were cohort, and 28 were cross-sectional studies. Of the total 120 publications, 49.1% focused on signs and symptoms, 23.3% on management, and 10.8% on pathophysiology. Ten publications focused on imaging studies. The results are also presented extensively in a narrative synthesis in separated sections (nomenclature, diagnosis, pathophysiology, risk factors, signs/symptoms, management).

conclusionsThe controversies in its definition have impaired proper recognition and management. The predominant symptoms were: fatigue, breathlessness, arthralgia, sleep difficulties, and chest pain. Recent reports also point to the risk of long-term sequela with cutaneous, respiratory, cardiovascular, musculoskeletal, mental health, neurologic, and renal involvement in those who survive the acute phase of the illness.

Indexed as

COVID-19FatigueHumansPost-Acute COVID-19 SyndromeRandomized Controlled Trials as TopicSARS-CoV-2Corona virusCOVID-19Long COVID-19Long haulers COVIDNovel Corona Virus 2019PASC post-acute sequela SARS-COV-2Post-acute COVID-19Post-acute SARS-CoV-2Post COVID-19 SyndromeSARS-Cov-2

Identifiers

PMID34319569
PMCPMC8317481
OpenAlexW3186444799

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.