ArticleMolecular neurobiology2021
NIR Laser Photobiomodulation Induces Neuroprotection in an In Vitro Model of Cerebral Hypoxia/Ischemia.
Article in Molecular neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07736092 (Impact of Perioperative Transcranial Photobiomodulation on Delayed Neurocognitive Recovery in Older Patients After Surgery), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Perioperative Transcranial Photobiomodulation on Delayed Neurocognitive Recovery in Older Patients After Surgery: a Randomized, Double-blind, Pseudo-modulation-controlled Preliminary Clinical Trial
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Photobiomodulation for the treatment of neuroinflammation: A systematic review of controlled laboratory animal studies.Frontiers in neuroscience · 2022Pooled it
- Effects of phototherapy on biopterin, neopterin, tryptophan, and behavioral neuroinflammatory reaction in patients with post-stroke depression.Scientific reports · 2024Trial
- Far-infrared irradiation restores mitochondrial dynamics to ameliorate ischemic stroke.Neural regeneration research · 2026Article
- Microglia heterogeneity in vascular dementia pathology.iScience · 2026Review
- Assessment of Dose-Dependent Effects of 1064 nm Photobiomodulation Therapy on Tenocyte- and Bursa-Derived Cell Proliferation In Vitro.Journal of clinical medicine · 2026Article
- Near-Infrared Laser Photobiomodulation Reduces Pro-Inflammatory Cytokines in an In Vitro Model of Bronchopulmonary Dysplasia: A Preliminary Report.Medical sciences (Basel, Switzerland) · 2026Article
- Application of non-invasive transcranial photobiomodulation in ischemic stroke: Mechanisms and current insights.iScience · 2026Review
- Pulsed Nd:YAG laser therapy accelerates fracture healing in a rat femoral osteotomy model.Bone & joint research · 2025Article
- Article
- Chronic administration of prebiotics and probiotics prevent pathophysiological hallmarks of Alzheimer's disease in the cortex of APP/PS1 mice.Frontiers in pharmacology · 2025Article
- Activation of testosterone-androgen receptor mediates cerebrovascular protection by photobiomodulation treatment in photothrombosis-induced stroke rats.CNS neuroscience & therapeutics · 2024Article
- Chronic administration of prebiotics and probiotics ameliorates pathophysiological hallmarks of Alzheimer's disease in a APP/PS1 transgenic mouse model.Frontiers in pharmacology · 2024Article
- Transcranial photobiomodulation for brain diseases: review of animal and human studies including mechanisms and emerging trends.Neurophotonics · 2024Review
- Revisiting Transcranial Light Stimulation as a Stroke Therapeutic-Hurdles and Opportunities.Translational stroke research · 2023Review
- Photons Induce Vesicular Exocytotic Release of Glutamate in a Power-Dependent Way.International journal of molecular sciences · 2023Article
- Application of stimuli-responsive nanomedicines for the treatment of ischemic stroke.Frontiers in bioengineering and biotechnology · 2023Review
- Photobiomodulation treatment inhibits neurotoxic astrocytic polarization and protects neurons in in vitro and in vivo stroke models.Neurochemistry international · 2023Article
- Hypoxia/Ischemia-Induced Rod Microglia Phenotype in CA1 Hippocampal Slices.International journal of molecular sciences · 2022Article
- Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Brain photobiomodulation (PBM) is an innovative treatment for a variety of neurological conditions, including cerebral ischemia. However, the capability of PBM for ischemic stroke needs to be further explored and its mechanisms of action remain currently unclear. The aim of the present research was to identify a treatment protocol capable of inducing neuroprotection and to investigate the molecular mechanisms activated by a dual-wavelength near infrared (NIR) laser source in an organotypic hippocampal slice model of hypoxia/ischemia. Hippocampal slices were exposed to oxygen and glucose deprivation (OGD) for 30 min followed by NIR laser light (fluence 3.71, 7.42, or 14.84 J/cm
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.