Evidence map›Paper›PMID 34319507›Full record

ArticleChinese journal of integrative medicine2021

Arsenic Trioxide Combining Leflunomide Activates Nrf2-ARE-HO-1 Signaling Pathway and Protects Heart Xenografts.

Teng-da Wang, Song-Lin Xu, Zheng-Yi Yu, Shao-Bin Ni, Cheng Zhang, Zhi-Xing Jiao

Abstract read
PubMed Publisher
In one paragraph

Article in Chinese journal of integrative medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Teng-da WangDepartment of Urology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150000, China.
Song-Lin XuDepartment of Urology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150000, China.
Zheng-Yi YuDepartment of Urology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150000, China.
Shao-Bin NiDepartment of Urology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150000, China.
Cheng ZhangDepartment of Urology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150000, China.
Zhi-Xing JiaoDepartment of Urology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150000, China. jiaozhixing@foxmail.com.
First Affiliated Hospital of Harbin Medical University · CNHarbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the molecular mechanisms underlying the effects of arsenic trioxide (As

methodsTransplantation of LVG hamster hearts to Lewis rats was performed by anastomosis of vessels in the neck using end-to-end anastomosis with a non-suture cuff technique. Four groups of recipient rats (n=6 in each) were treated with normal saline (control), As

resultsExpression of Nrf2-ARE-HO-1 signaling pathway was upregulated in heart xenografts in rats treated with As

conclusionCombination treatment with As

Indexed as

Heart TransplantationNF-E2-Related Factor 2AnimalsArsenic TrioxideCricetinaeHeme Oxygenase-1HeterograftsLeflunomideRatsRats, Inbred LewSignal TransductionArsenic TrioxideHeme Oxygenase-1LeflunomideNF-E2-Related Factor 2arsenic trioxideinfiltrationinflammationleflunomideNrf2-ARE-HO-1 signaling pathwayxenotransplantation

Identifiers

PMID34319507
OpenAlexW3183670672

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.