Evidence map›Paper›PMID 34319427›Full record

Trial reportEuropean journal of nutrition2022

Temporal and mediation relations of weight loss, and changes in insulin resistance and blood pressure in response to 2-year weight-loss diet interventions: the POUNDS Lost trial.

Liyuan Han, Tao Zhang, Dingyun You, Wei Chen, George Bray, Frank Sacks, Lu Qi

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00072995 (Preventing Overweight Using Novel Dietary Strategies), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00072995 nacompletednot on this map

Preventing Overweight Using Novel Dietary Strategies (Pounds Lost)

TypeinterventionalSponsorBrigham and Women's HospitalRan2003 to 2007Enrolled811ConditionsCardiovascular Diseases, Heart Diseases, ObesityArmsFour Diets Differing in Macronutrient Composition, Diets Low in Saturated Fat
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Liyuan HanHwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, People's Republic of China.
Tao ZhangDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, 70112, USA.
Dingyun YouDepartment of Science and Technology, Kunming Medical University, Kunming, 650500, China.
Wei ChenDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, 70112, USA.
George BrayPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
Frank SacksDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Lu QiDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, 70112, USA. lqi1@tulane.edu.
Harvard University · USTulane University · USKunming Medical University · CNPennington Biomedical Research Center · USUniversity of Chinese Academy of Sciences · CN

Funding

Ningbo Health Branding Subject Fund PPXK2018-02Ningbo Science and Technology Project 202002N3152Sanming Project of Medicine in Shenzhen SZSM201803080the Innovative Talent Support Plan of the Medical and Health Technology Project in Zhejiang Province 2021422878
6 · The paper itself

Abstract

purposeBody weight and insulin resistance (IR) are closely correlated, and their temporal sequences in affecting blood pressure (BP) remain poorly defined. We examined the temporal sequences of weight loss and IR change, and their relations with BP in the Pounds Lost trial, a randomized weight-loss diet intervention study.

methodsThe present study included overweight/obese adults, who were randomized in a 2 × 2 factorial design to low-calorie diets containing 20 or 40% fat and 15 or 25% protein (diets with 65, 55, 45 and 35% carbohydrate). Weight, IR, systolic and diastolic BP levels were measured at baseline, 6 and 24 months. After excluding the subjects who took antihypertensive drugs, cross-lagged path and mediation analyses were performed among 540 participants.

resultsAfter adjusting for age, race, sex, and diet groups, the cross-lagged path coefficient from baseline weight to 24-month IR (β

conclusionsOur data indicate that weight loss precedes change of IR, which mediates a significant proportion of the effects of weight loss on changes of BP in response to the diet interventions.

trial registrationNCT00072995 First Posted November 17, 2003 Last Update Posted January 30, 2013 this study was not 'retrospectively registered'.

Indexed as

Insulin ResistanceAdultBlood PressureDiet, ReducingGenotypeHumansInsulinOverweightWeight LossInsulinBlood pressureBody weightInsulin resistanceObese adultOverweight adults

Identifiers

PMID34319427
OpenAlexW3185935882

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.