Evidence map›Paper›PMID 34319404›Full record

ArticleThe Biochemical journal2021

Manipulating the exposome to enable better ageing.

Paul G Shiels, Johanna Painer, Barbara Natterson-Horowitz, Richard J Johnson, Jaime J Miranda, Peter Stenvinkel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Biochemical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Chronic Kidney Disease and Cellular Senescence.International journal of molecular sciences · 2026
    Review
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  9. Harnessing Evolution and Biomimetics to Enhance Planetary Health: Kidney Insights.Journal of the American Society of Nephrology : JASN · 2025
    Review
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  11. Review
  12. Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paul G ShielsWolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, U.K.ORCID 0000-0002-7577-9843
Johanna PainerResearch Institute of Wildlife Ecology, Department of Interdisciplinary Life Sciences, University of Veterinary Medicine, Savoyenstreet 1, 1160 Vienna, Austria.
Barbara Natterson-HorowitzDepartment of Human Evolutionary Biology, UCLA Division of Cardiology, Co-Director, Evolutionary Medicine Program at UCLA, Harvard University, California, U.S.A.
Richard J JohnsonDivision of Renal Diseases, University of Colorado Anschutz Medical Campus, Aurora, Colorado, U.S.A.
Jaime J MirandaCRONICAS Centre of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.
Peter StenvinkelDivision of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Campus Flemingsberg, Stockholm, Sweden.ORCID 0000-0002-8785-4820

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The sum total of life course exposures creates an exposome that has a significant impact on age-related health. Understanding the interplay between exposome factors and the (epi) genome, offers pertinent insights into the ageing process and its relationship with the accumulation of allostatic load. We propose to exploit this to develop a biomimetic approach that will provide insight into how evolution through natural selection in other species has solved many age related human health issues. In particular, we will emphasise the need to reconnect a more mechanistic approach to medical science with a broader natural sciences approach, using biomimetics to mitigate the global burden of age related ill health. In particular, we will discuss how such an approach indicates leverage of the activities of the Nrf 2 gene to enhance health span via reintroduction of the classical 'Food as Medicine' concept, including modulation of the microbiome and the creation of more salutogenic and biophilic environments. Additionally, we will discuss how this approach integrates with novel and developing senotherapies.

Indexed as

ExposomeAgingAllostasisDNA MethylationEpigenesis, GeneticGastrointestinal MicrobiomeHealthHumansModels, TheoreticalNF-E2-Related Factor 2Social EnvironmentNFE2L2 protein, humanNF-E2-Related Factor 2ageingallostatic loadbiomimeticsexposomemicrobiomeNrf2

Identifiers

PMID34319404
PMCPMC8331090

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.