ArticleAnalytical chemistry2021
Combined Analysis of Multiple Glycan-Array Datasets: New Explorations of Protein-Glycan Interactions.
Article in Analytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Deciphering the Structure-Immunomodulatory Function Relationships of Homopolysaccharides.Nutrients · 2026Review
- The receptor binding properties of H5Ny influenza A viruses have evolved to bind to avian-type mucin-like O-glycans.PLoS pathogens · 2026Article
- Atom-level machine learning of protein-glycan interactions and cross-chiral recognition in glycobiology.Science advances · 2025Article
- Chemical tools to study and modulate glycan-mediated host-bacteria interactions.Current opinion in chemical biology · 2025Review
- Identification of SARS-CoV-2-binding lectins on a commercial lectin array.Scientific reports · 2025Article
- Expedient Assembly of MultiantennaryJournal of the American Chemical Society · 2025Article
- Multiplexed glycan immunofluorescence identification of pancreatic cancer cell subpopulations in both tumor and blood samples.Science advances · 2025Article
- Updates implemented in version 4 of the GlyCosmos Glycoscience Portal.Analytical and bioanalytical chemistry · 2025Article
- Toward spatial glycomics and glycoproteomics: Innovations and applications.BBA advances · 2025Article
- Boltzmann Model Predicts Glycan Structures from Lectin Binding.Analytical chemistry · 2024Article
- A Boltzmann model predicts glycan structures from lectin binding.bioRxiv : the preprint server for biology · 2024Article
- New carbohydrate binding domains identified by phage display based functional metagenomic screens of human gut microbiota.Communications biology · 2023Article
- Proximity labeling technologies to illuminate glycan-protein interactions.Current opinion in chemical biology · 2023Review
- VT68.2: An Antibody to Chondroitin Sulfate Proteoglycan 4 (CSPG4) Displays Reactivity against a Tumor-Associated Carbohydrate Antigen.International journal of molecular sciences · 2023Article
- A Useful Guide to Lectin Binding: Machine-Learning Directed Annotation of 57 Unique Lectin Specificities.ACS chemical biology · 2022Article
- CarboGrove: a resource of glycan-binding specificities through analyzed glycan-array datasets from all platforms.Glycobiology · 2022Article
- CarbArrayART: a new software tool for carbohydrate microarray data storage, processing, presentation, and reporting.Glycobiology · 2022Article
- GlyNet: a multi-task neural network for predicting protein-glycan interactions.Chemical science · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Glycan arrays are indispensable for learning about the specificities of glycan-binding proteins. Despite the abundance of available data, the current analysis methods do not have the ability to interpret and use the variety of data types and to integrate information across datasets. Here, we evaluated whether a novel, automated algorithm for glycan-array analysis could meet that need. We developed a regression-tree algorithm with simultaneous motif optimization and packaged it in software called MotifFinder. We applied the software to analyze data from eight different glycan-array platforms with widely divergent characteristics and observed an accurate analysis of each dataset. We then evaluated the feasibility and value of the combined analyses of multiple datasets. In an integrated analysis of datasets covering multiple lectin concentrations, the software determined approximate binding constants for distinct motifs and identified major differences between the motifs that were not apparent from single-concentration analyses. Furthermore, an integrated analysis of data sources with complementary sets of glycans produced broader views of lectin specificity than produced by the analysis of just one data source. MotifFinder, therefore, enables the optimal use of the expanding resource of the glycan-array data and promises to advance the studies of protein-glycan interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.