Evidence map›Paper›PMID 34319008›Full record

ArticleCancer reports (Hoboken, N.J.)2022

Pulmonary surveillance in pediatric hematopoietic stem cell transplant: A multinational multidisciplinary survey.

Shivanthan Shanthikumar, William A Gower, Matthew Abts, Deborah R Liptzin, Elizabeth K Fiorino, Anne Stone, Saumini Srinivasan, Timothy J Vece, Nour Akil, Theresa Cole and 2 more

Abstract read
In one paragraph

Article in Cancer reports (Hoboken, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Multiple breath washout and oscillometry after allogenic HSCT: a scoping review.European respiratory review : an official journal of the European Respiratory Society · 2023
    Article
  6. Pulmonary complications after hematopoietic stem cell transplantation in children: a functional and tomographic evaluation.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shivanthan ShanthikumarRespiratory and Sleep Medicine, Royal Children's Hospital, Parkville, Victoria, Australia.ORCID 0000-0001-6000-3180
William A GowerDivision of Pediatric Pulmonology, Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina, USA.
Matthew AbtsSeattle Children's Hospital, Seattle, Washington, USA.
Deborah R LiptzinDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Elizabeth K FiorinoDivision of Pulmonology, Allergy, and Immunology, Department of Pediatrics, Weill Cornell Medicine, New York, New York, USA.
Anne StoneDivision of Pulmonology, Department of Pediatrics, Oregon Health & Science University, Portland, Oregon, USA.ORCID 0000-0001-6004-4257
Saumini SrinivasanDivision of Pulmonology, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Timothy J VeceDivision of Pediatric Pulmonology, Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina, USA.
Nour AkilDivision of Pulmonology, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Theresa ColeAllergy and Immunology, Royal Children's Hospital, Parkville, Victoria, Australia.
Kenneth R CookeDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Samuel B GoldfarbDivision of Pulmonary and Sleep Medicine, Department of Pediatrics, School of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHematopoietic Stem Cell Transplant (HSCT) is an established treatment for malignant and non-malignant conditions and pulmonary disease is a leading cause of late term morbidity and mortality. Accurate and early detection of pulmonary complications is a critical step in improving long term outcomes. Existing guidelines for surveillance of pulmonary complications post-HSCT contain conflicting recommendations.

aimTo determine the breadth of current practice in monitoring for pulmonary complications of pediatric HSCT.

methodsAn institutional review board approved, online, anonymous multiple-choice survey was distributed to HSCT and pulmonary physicians from the United States of America and Australasia using the REDcap platform. The survey was developed by members of the American Thoracic Society Working Group on Complications of Childhood Cancer, and was designed to assess patient management and service design.

resultsA total of 40 (34.8%) responses were received. The majority (62.5%) were pulmonologists, and 82.5% were from the United States of America. In all, 67.5% reported having a protocol for monitoring pulmonary complications and 50.0% reported adhering "well" or "very well" to protocols. Pulmonary function tests (PFTs) most commonly involved spirometry and diffusion capacity for carbon monoxide. The frequency of PFTs varied depending on time post-HSCT and presence of complications. In all, 55.0% reported a set threshold for a clinically significant change in PFT.

conclusionsThese results illustrate current variation in surveillance for pulmonary complications of pediatric HSCT. The results of this survey will inform development of future guidelines for monitoring of pulmonary complications after pediatric HSCT.

Indexed as

Hematopoietic Stem Cell TransplantationLung DiseasesAustralasiaChildHumansLungSurveys and Questionnairesdiagnostic screening programspediatricsrespiratory tract diseasesstem cell transplantation

Identifiers

PMID34319008
PMCPMC9124519

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.