Evidence map›Paper›PMID 34318967›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2021

Diabetic mitochondria are resistant to palmitoyl CoA inhibition of respiration, which is detrimental during ischemia.

M Kerr, K M J H Dennis, C A Carr, W Fuller, G Berridge, S Rohling, C L Aitken, C Lopez, R Fischer, J J Miller and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Effects of Lipid Overload on Heart in Metabolic Diseases.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2021
    Review
  4. Diabetic mitochondria are resistant to palmitoyl CoA inhibition of respiration, which is detrimental during ischemia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

M KerrDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
K M J H DennisDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
C A CarrDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
W FullerInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
G BerridgeTarget Discovery Institute, University of Oxford, Oxford, UK.
S RohlingDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
C L AitkenDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
C LopezDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
R FischerTarget Discovery Institute, University of Oxford, Oxford, UK.
J J MillerDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
K ClarkeDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
D J TylerDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
L C HeatherDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
University of Oxford · GBAarhus University · DKUniversity of Glasgow · GB

Funding

British Heart Foundation FS/15/68/32042British Heart Foundation FS/17/58/33072British Heart Foundation FS/19/18/34252British Heart Foundation PG/19/5/34150British Heart Foundation SP/16/3/32317
6 · The paper itself

Abstract

The bioactive lipid intermediate palmitoyl CoA (PCoA) can inhibit mitochondrial ADP/ATP transport, though the physiological relevance of this regulation remains unclear. We questioned whether myocardial ischemia provides a pathological setting in which PCoA regulation of ADP/ATP transport would be beneficial, and secondly, whether the chronically elevated lipid content within the diabetic heart could make mitochondria less sensitive to the effects of PCoA. PCoA acutely decreased ADP-stimulated state 3 respiration and increased the apparent K

Indexed as

IschemiaMyocardiumPalmitoyl Coenzyme AAdenosine TriphosphateAnimalsCell RespirationDiabetes Mellitus, Type 2Energy MetabolismMaleMitochondria, HeartOxygen ConsumptionRatsRats, WistarAdenosine TriphosphatePalmitoyl Coenzyme Adiabetesenergeticsfatty acidsheartischemiamitochondria

Identifiers

PMID34318967
PMCPMC8662312
OpenAlexW3184130140

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.