Evidence map›Paper›PMID 34318855›Full record

ArticleMolecular omics2021

Analysis of pancreatic extracellular matrix protein post-translational modifications

Dylan Nicholas Tabang, Yusi Cui, Daniel M Tremmel, Megan Ford, Zihui Li, Sara Dutton Sackett, Jon S Odorico, Lingjun Li

Open access · greenAbstract read
In one paragraph

Article in Molecular omics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Dylan Nicholas TabangDepartment of Chemistry, University of Wisconsin-Madison, 777 Highland Ave., Madison, WI, 53706, USA. lingjun.li@wisc.edu.ORCID 0000-0002-2151-3855
Yusi CuiDepartment of Chemistry, University of Wisconsin-Madison, 777 Highland Ave., Madison, WI, 53706, USA. lingjun.li@wisc.edu.
Daniel M TremmelDepartment of Surgery, Division of Transplantation, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID 0000-0002-1725-5582
Megan FordDepartment of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID 0000-0002-4377-3674
Zihui LiDepartment of Chemistry, University of Wisconsin-Madison, 777 Highland Ave., Madison, WI, 53706, USA. lingjun.li@wisc.edu.ORCID 0000-0003-0865-4634
Sara Dutton SackettDepartment of Surgery, Division of Transplantation, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID 0000-0003-0738-4767
Jon S OdoricoDepartment of Surgery, Division of Transplantation, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID 0000-0003-1096-464X
Lingjun LiDepartment of Chemistry, University of Wisconsin-Madison, 777 Highland Ave., Madison, WI, 53706, USA. lingjun.li@wisc.edu.ORCID 0000-0003-0056-3869
University of Wisconsin–Madison · US

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Mass Spectrometric Studies of Neuropeptides in FeedingR01DK071801 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI LINGJUN LI · 2006 to 2026
$6.7M
Di-Leu-enabled multiplexed quantitation for biomarker discovery and validation in Alzheimer's diseaseRF1AG052324 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2018 to 2018
$2.4M
Acquisition of a High-Field Dual Source FTICR-MS for Pharmaceutical ResearchS10RR029531 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2011 to 2011
$2.1M
MULTIPLEX CHEMICAL TAGS FOR HIGH-THROUGHPUT GLYCAN AND GLYCOPEPTIDE QUANTITATION AND CHARACTERIZATIONU01CA231081 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2018 to 2020
$1.3M
Transformational platform for regenerating autologous transplantable endocrine tissue from human pancreatic matrix and pluripotent stem cellsR21AI126419 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI ODORICO, JON S · 2016 to 2017
$408k
Probing the human pancreatic and islet matrisomeF31DK125021 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI TREMMEL, DANIEL M · 2020 to 2021
$69k
NCATS NIH HHS UL1 TR002373NCI NIH HHS U01 CA231081NCRR NIH HHS S10 RR029531NIAID NIH HHS R21 AI126419NIA NIH HHS RF1 AG052324NIDDK NIH HHS F31 DK125021NIDDK NIH HHS R01 DK071801
6 · The paper itself

Abstract

The pancreas is a vital organ with digestive and endocrine roles, and diseases of the pancreas affect millions of people yearly. A better understanding of the pancreas proteome and its dynamic post-translational modifications (PTMs) is necessary to engineer higher fidelity tissue analogues for use in transplantation. The extracellular matrix (ECM) has major roles in binding and signaling essential to the viability of insulin-producing islets of Langerhans. To characterize PTMs in the pancreas, native and decellularized tissues from four donors were analyzed.

Indexed as

Extracellular Matrix ProteinsProteomicsChromatographyHumansHydrophobic and Hydrophilic InteractionsMass SpectrometryPancreasProtein Processing, Post-TranslationalStatic ElectricityExtracellular Matrix Proteins

Identifiers

PMID34318855
PMCPMC8511275
OpenAlexW3184184636

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.