ArticleImmunity, inflammation and disease2021
Alkaloid leonurine exerts anti-inflammatory effects via modulating MST1 expression in trophoblast cells.
Article in Immunity, inflammation and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Leonurine: A Multifaceted Bioactive Alkaloid-From Pharmacological Mechanisms to Clinical Translation: A Narrative Review.Health science reports · 2026Article
- MST1 modulates inflammatory responses by targeting the NF-κB/NLRP3 pathway in LPS-induced acute lung injury.Histochemistry and cell biology · 2025Article
- The NFκB Signaling Pathway Is Involved in the Pathophysiological Process of Preeclampsia.Geburtshilfe und Frauenheilkunde · 2024Article
- Leonurine: a comprehensive review of pharmacokinetics, pharmacodynamics, and toxicology.Frontiers in pharmacology · 2024Review
- MST1/2 in inflammation and immunity.Cell adhesion & migration · 2023Review
- The Gut Microbiota of Pregnant Rats Alleviates Fetal Growth Restriction by Inhibiting the TLR9/MyD88 Pathway.Journal of microbiology and biotechnology · 2023Article
- A literature review: mechanisms of antitumor pharmacological action of leonurine alkaloid.Frontiers in pharmacology · 2023Review
- Alkaloid leonurine exerts anti-inflammatory effects via modulating MST1 expression in trophoblast cells.Immunity, inflammation and disease · 2021Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPre-eclampsia (PE) is mainly attributed to the inflammation of trophoblast cells in pregnant women, which results in damage to the maternal organs and growth retardation of the fetus. Alkaloid leonurine (LNR) is a plant compound and has anti-inflammatory effects. Here we aimed to investigate the effects of LNR on human and mouse trophoblast cells and the underlying mechanisms.
methodsThe levels of the inflammatory factors in trophoblast cells under lipopolysaccharides (LPS) stimulation were analyzed with ELISA. Western blot was employed to examine the protein expression. Trophoblast cells in Mammalian ste20-like kinase 1 (MST1
resultsOur data showed that LNR exhibited anti-inflammatory effects and suppressed the NF-κB signaling by inhibiting LPS-induced inflammation in trophoblast cells. LNR upregulated the expression of MST1, and the anti-inflammatory role of LNR was greatly relieved in MST1-knockout trophoblast cells, although it displayed weak roles in NF-κB signaling.
conclusionLNR exhibits anti-inflammatory effects on human and mouse trophoblast cells by upregulating MST1 in the NF-κB signal pathway.
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