Evidence map›Paper›PMID 34318355›Full record

ArticleDigestive diseases and sciences2022

Periodic Colonoscopies Are Associated with Improved Survival and Prognosis of Colorectal Cancer in Ulcerative Colitis.

Neeraj Narula, Anne Hu, Geoffrey C Nguyen, Jagadish Rangrej, John K Marshall

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Article in Digestive diseases and sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Neeraj NarulaDepartment of Medicine (Division of Gastroenterology) and Farncombe Family Digestive Health Research Institute, McMaster University, McMaster University Medical Centre, 1280 Main St West, Unit 3V28, Hamilton, ON, L8S 4K1, Canada. Neeraj.narula@medportal.ca.ORCID 0000-0002-1536-8436
Anne HuDepartment of Medicine (Division of Gastroenterology) and Farncombe Family Digestive Health Research Institute, McMaster University, McMaster University Medical Centre, 1280 Main St West, Unit 3V28, Hamilton, ON, L8S 4K1, Canada.
Geoffrey C NguyenMount Sinai Hospital Inflammatory Bowel Disease Centre, University of Toronto, Toronto, ON, Canada.
Jagadish RangrejHealth Data Science Branch, Ontario Ministry of Health and Long-Term Care, Toronto, ON, Canada.
John K MarshallDepartment of Medicine (Division of Gastroenterology) and Farncombe Family Digestive Health Research Institute, McMaster University, McMaster University Medical Centre, 1280 Main St West, Unit 3V28, Hamilton, ON, L8S 4K1, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND STUDY

aimsThis study aimed to identify whether ulcerative colitis (UC) patients who develop colorectal cancer (CRC) present at earlier stages of CRC and have improved survival if prior to their CRC diagnosis, they underwent intermittent follow-up colonoscopies compared to those who have no follow-up colonoscopies.

methodsPatients with UC who developed primary CRC were identified using data provided by the Institute for Clinical Evaluative Sciences. We defined low-risk CRC stage as estimated 5-year survival ≥ 80% compared to high-risk CRC as 5-year survival < 80%.

resultsA total of 421 patients were identified with UC and CRC. The 15-year mortality rate was significantly higher in those who did not have follow-up colonoscopy (33/74; 44.6%) compared to the follow-up group (105/347; 30.3%) (p = 0.0172). Among the 219 patients with UC with staging information available, patients who did not have follow-up colonoscopy were more likely to present with high-risk CRC (24/31; 77.4%) compared with patients who had follow-up colonoscopies (88/188; 44.4%) (p = 0.0016). Those who underwent follow-up colonoscopies at average intervals ≤ 3 years presented with high-risk CRC 41.3% of the time, which was less than the 48.6% in those with less frequent colonoscopies and 77.4% in those with no follow-up (p = 0.0048).

conclusionsPatients with UC who underwent intermittent follow-up colonoscopies had CRC detected at earlier stages and improvement in all-cause mortality, compared to those who with no follow-up colonoscopies. This may support regular surveillance colonoscopies for patients with UC.

Indexed as

Colitis, UlcerativeColorectal NeoplasmsColonoscopyHumansNeoplasm StagingPrognosisColonoscopyColorectal cancerInflammatory bowel diseaseScreeningSurveillance

Identifiers

PMID34318355

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