Evidence map›Paper›PMID 34318127›Full record

ArticleJTCVS techniques2021

Safety of perioperative cerebrospinal fluid drain as a protective strategy during descending and thoracoabdominal open aortic repair.

Mohamed Abdelbaky, Dimitra Papanikolaou, Mohammad A Zafar, Hesham Ellauzi, Maryam Shaikh, Bulat A Ziganshin, John A Elefteriades

Open access · goldAbstract read
In one paragraph

Article in JTCVS techniques, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Mohamed AbdelbakyAortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Conn.
Dimitra PapanikolaouAortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Conn.
Mohammad A ZafarAortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Conn.
Hesham EllauziAortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Conn.
Maryam ShaikhAortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Conn.
Bulat A ZiganshinAortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Conn.
John A ElefteriadesAortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Conn.
Yale University · USYale New Haven Hospital · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

objectiveWe present our experience with routine application of the cerebrospinal fluid (CSF) drain (CSFD) during open aortic repair.

methodsWe retrospectively reviewed 100 patients with descending thoracic aortic aneurysm (DTAA) or thoracoabdominal aortic aneurysm (TAAA) or who underwent CSFD insertion before open repair between 2006 and 2017. All CSFDs were inserted by the cardiovascular anesthesia team. The goal was to keep intracranial pressure <10 mm Hg during the surgical procedure by draining CSF at a rate of 20 to 30 mL/h. Postoperatively, CSFD was set to maintain the lumbar pressure <10 mm Hg to reduce the risk of postoperative paraplegia. CSFD was part of our standard cord protection regimen.

resultsThe mean patient age was 65.4 ± 11.7 years, and 60 (60%) were male. A CSFD was successfully inserted in all patients. The mean hospital length of stay was 11.9 ± 11.8 days, and hospital mortality was 6%. Postoperative transient paresis was observed in 4 patients (4%), and permanent paraplegia was seen in 2 (2%). CSFD-related complications were reported in 14 patients (14%). Complications included persistent CSF leakage and blood-tinged CSF with and without intracranial hemorrhage and spinal cutaneous fistula in 7 (7%), 9 (9%), and 1 (1%), respectively. Long-term survival was excellent (68.4% at 10 years).

conclusionsCSFD is a safe practice when applied routinely as an adjunct strategy to prevent paraplegia in surgical management of DTAA and TAAA. We feel that this contributed to good early and late clinical results.

Indexed as

CSF, cerebrospinal fluidCSFD, cerebrospinal fluid drainCTA, computed tomography angiographyCT, computed tomographydescending aneurysmDTAA, descending thoracic aortic aneurysmMRA, magnetic resonance angiographySCI, spinal cord ischemiaspinal protectionTAAA, thoracoabdominal aortic aneurysmthoracoabdominal aneurysm

Identifiers

PMID34318127
PMCPMC8300913
OpenAlexW3120448258

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.