Evidence map›Paper›PMID 34317556›Full record

ArticleJACC. Case reports2021

Biopsy Evidence of Sequential Transthyretin and Immunoglobulin Light-Chain Cardiac Amyloidosis in the Same Patient.

Giuseppe Vergaro, Vincenzo Castiglione, Roberta Poletti, Gabriele Buda, Angela Pucci, Veronica Musetti, Dario Genovesi, Alberto Aimo, Claudio Passino, Michele Emdin

Open access · goldAbstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Cardiac amyloidosis: From diagnosis to therapeutics breakthroughs.World journal of experimental medicine · 2026
    Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Assessment of ATTR Cardiac Amyloidosis in Patients with Left Ventricular Hypertrophy Using Tc-99m Pyrophosphate Scintigraphy.Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Giuseppe VergaroInstitute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
Vincenzo CastiglioneInstitute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
Roberta PolettiFondazione Toscana Gabriele Monasterio, Pisa, Italy.
Gabriele BudaHematology Department, University of Pisa, Pisa, Italy.
Angela PucciHistopathology Department, University of Pisa, Pisa, Italy.
Veronica MusettiFondazione Toscana Gabriele Monasterio, Pisa, Italy.
Dario GenovesiFondazione Toscana Gabriele Monasterio, Pisa, Italy.
Alberto AimoInstitute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
Claudio PassinoInstitute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
Michele EmdinInstitute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
Fondazione Toscana Gabriele Monasterio · ITScuola Superiore Sant'Anna · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently adopted diagnostic flow charts consider transthyretin and light-chain cardiac amyloidosis as mutually exclusive. Here, we report for the first time, to our knowledge, the demonstration of a biopsy-proven dual pathology in an 80-year-old man with sequential development of both wild-type transthyretin amyloidosis and light-chain cardiac amyloidosis cardiomyopathy over a 3-year timespan. (

Indexed as

99mTc-HMDP, 99mTc-hydroxymethylene diphosphonateAL amyloidosisAL, immunoglobulin light-chain amyloidosisATTR amyloidosisATTR, transthyretin amyloidosisCA, cardiac amyloidosiscardiac amyloidosisCMR, cardiac magnetic resonanceHF, heart failurehs-cTnT, high-sensitivity cardiac troponin TIg, immunoglobulinLVEF, left ventricular ejection fractionLV, left ventricularNT-proBNP, N-terminal pro–B-type natriuretic peptide

Identifiers

PMID34317556
PMCPMC8311035
OpenAlexW3138140315

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.