Evidence map›Paper›PMID 34317346›Full record

ArticleJACC. Case reports2020

A Novel Variant in

Ida Surakka, Whitney E Hornsby, Linda Farhat, Melvyn Rubenfire, Lars G Fritsche, Kristian Hveem, Y Eugene Chen, Robert D Brook, Cristen J Willer, Richard L Weinberg

Open access · goldAbstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Ida SurakkaUniversity of Michigan, Michigan Medicine, Ann Arbor, Michigan.
Whitney E HornsbyUniversity of Michigan, Michigan Medicine, Ann Arbor, Michigan.
Linda FarhatUniversity of Michigan, Michigan Medicine, Ann Arbor, Michigan.
Melvyn RubenfireUniversity of Michigan, Michigan Medicine, Ann Arbor, Michigan.
Lars G FritscheUniversity of Michigan, Michigan Medicine, Ann Arbor, Michigan.
Kristian HveemK.G. Jebsen Center for Genetic Epidemiology and Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Y Eugene ChenUniversity of Michigan, Michigan Medicine, Ann Arbor, Michigan.
Robert D BrookUniversity of Michigan, Michigan Medicine, Ann Arbor, Michigan.
Cristen J WillerUniversity of Michigan, Michigan Medicine, Ann Arbor, Michigan.
Richard L WeinbergUniversity of Michigan, Michigan Medicine, Ann Arbor, Michigan.
Michigan Medicine · USNorwegian University of Science and Technology · NOUniversity of Michigan–Ann Arbor · US

Funding

Using genetics to discover mechanisms of myocardial infarctionR01HL109946 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YUQING Eugene CHEN, Ida Liisa Surakka · 2011 to 2026
$8.9M
Genetic Predisposition To Thoracic Aortic Aneurysms/DissectionsR01HL109942 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MILEWICZ, DIANNA M · 2012 to 2023
$7.5M
Using genetic variation to study biology of blood lipids & coronary heart diseaseR01HL127564 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Pradeep Natarajan, Gina Marie Peloso · 2015 to 2026
$7.3M
Using Genetics to Inform Mechanism of Cardiovascular DiseaseR35HL135824 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WILLER, CRISTEN J · 2017 to 2022
$5.4M
Integrative analysis to uncover biology of blood lipids & coronary heart diseaseR01HL142023 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WILLER, CRISTEN J, ZHOU, XIANG · 2018 to 2019
$859k
NHLBI NIH HHS R01 HL109942NHLBI NIH HHS R01 HL109946NHLBI NIH HHS R01 HL127564NHLBI NIH HHS R01 HL142023NHLBI NIH HHS R35 HL135824
6 · The paper itself

Abstract

A novel frameshift variant was identified in

Indexed as

apoB, apolipoprotein Bapolipoprotein B loss-of-functionFHBL, familial hypobetalipoproteinemiahypobetalipoproteinemiaLDL-C, low-density lipoprotein cholesterolLoF, loss-of-functionlow-density lipoprotein cholesterol

Identifiers

PMID34317346
PMCPMC8301695
OpenAlexW3028233253

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.