Evidence map›Paper›PMID 34317309›Full record

ArticleJACC. Case reports2020

Immune Checkpoint Inhibitor-Associated Myocarditis: A Run of Bad Luck or Rather Deficient-Monitoring Protocol?

Grigorios Chatzantonis, Georg Evers, Claudia Meier, Michael Bietenbeck, Anca Florian, Karin Klingel, Annalen Bleckmann, Ali Yilmaz

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Immune checkpoint inhibitor-associated myocarditis: a historical and comprehensive review.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  4. Article
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Grigorios ChatzantonisDepartment of Cardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany.
Georg EversDepartment of Medicine A, Hematology, Oncology and Pulmonary Medicine, University Hospital Münster, Münster, Germany.
Claudia MeierDepartment of Cardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany.
Michael BietenbeckDepartment of Cardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany.
Anca FlorianDepartment of Cardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany.
Karin KlingelDivision of Cardiopathology, Institute of Pathology and Neuropathology, University Hospital Tübingen, Tübingen, Germany.
Annalen BleckmannDepartment of Medicine A, Hematology, Oncology and Pulmonary Medicine, University Hospital Münster, Münster, Germany.
Ali YilmazDepartment of Cardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune checkpoint inhibitors (ICIs) can induce immunity-related adverse events. We demonstrate the clinical use of cardiac magnetic resonance and endomyocardial biopsy in the diagnosis and subsequent monitoring of ICI-associated myocarditis, suggesting the need to establish and evaluate a cardiac monitoring protocol for patients under ICI therapy. (

Indexed as

CMRCMR, cardiac magnetic resonanceICI, immune checkpoint inhibitorirAEirAE, immune-related adverse eventLGE, late gadolinium enhancementLVEF, left ventricular ejection fractionLV, left ventricularMMF, mycophenolate mofetilmyocarditisNSCLC, non–small cell lung cancerPD-L, programmed death-ligandPD, programmed deathpembrolizumabRR, reference rangeventricular tachycardiaVT, ventricular tachycardia

Identifiers

PMID34317309
PMCPMC8298681

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.