Evidence map›Paper›PMID 34317250›Full record

ArticleJACC. Case reports2020

Use of PCSK9 Inhibitors in Solid Organ Transplantation Recipients.

Bruce A Warden, Tina Kaufman, Jessica Minnier, P Barton Duell, Sergio Fazio, Michael D Shapiro

Open access · goldAbstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Observational
  2. Metabolic syndrome after liver transplantation: A silent threat to long-term success.World journal of gastrointestinal pharmacology and therapeutics · 2025
    Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Dyslipidemia in Transplant Patients: Which Therapy?Journal of clinical medicine · 2022
    Review
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Bruce A WardenCenter for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon.
Tina KaufmanCenter for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon.
Jessica MinnierCenter for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon.
P Barton DuellCenter for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon.
Sergio FazioCenter for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon.
Michael D ShapiroCenter for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon.
Oregon Health & Science University · USAtrium Health Wake Forest Baptist · US

Funding

Scholars in Women's Health Research Across the LifespanK12HD043488 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI MYATT, LESLIE · 2002 to 2023
$10.4M
Functional and structural correlates of PCSK9 association with lipoproteinsR01HL132985 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI PAMIR, NATHALIE · 2016 to 2024
$4.2M
NHLBI NIH HHS R01 HL132985NICHD NIH HHS K12 HD043488
6 · The paper itself

Abstract

Standard lipid-lowering therapies in solid organ transplantations pose challenges due to interactions with immunosuppressants. Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) represent a new class of lipid-lowering therapies with potential promise in this population. We describe PCSK9i as an efficacious and safe option for management of hypercholesterolemia in solid organ transplantations. (

Indexed as

ASCVD, atherosclerotic cardiovascular diseaseCAV, cardiac allograft vasculopathyCVD, cardiovascular diseasedyslipidemiaFH, familial hypercholesterolemiaLDL-C, low-density lipoprotein cholesterolLLT, lipid-lowering therapyPCSK9i, proprotein convertase subtilisin/kexin type 9 inhibitorPCSK9, proprotein convertase subtilisin/kexin type 9proprotein convertase subtilisin/kexin type 9 inhibitorssolid organ transplantationSOT, solid organ transplantation

Identifiers

PMID34317250
PMCPMC8311616
OpenAlexW3005888994

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.