ArticleClinical parkinsonism & related disorders2020
Heightened risk of early vocal fold motion impairment onset and dysphagia in the parkinsonian variant of multiple system atrophy: a comparative study.
Article in Clinical parkinsonism & related disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Velopharyngeal Insufficiency and Impaired Tongue Movement Indicate Neuromuscular Disorders: A 10-Year Statistical Study in a Single Tertiary Institution.Journal of clinical medicine · 2025Article
- Esophageal Dysmotility in Multiple System Atrophy: A Retrospective Cross-Sectional Study.Journal of clinical medicine · 2024Article
- Vocal Fold Motion Impairment in Neurodegenerative Diseases.Journal of clinical medicine · 2024Review
- Management and Treatment for Dysphagia in Neurodegenerative Disorders.Journal of clinical medicine · 2023Review
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7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe compared differences in frequency and timing of onset of the following clinical events between the cerebellar and parkinsonian variants of multiple system atrophy (MSA-C and MSA-P, respectively): type of operation including tracheostomy and/or aspiration prevention surgery, vocal fold motion impairment (VFMI), sleep apnea (SA), introduction of mechanical ventilation (MV), and dysphagia. The risks of these events cooccurring with either MSA-C or MSA-P were compared.
methodsWe retrospectively assessed clinical outcomes only of patients with MSA who presented at the Department of Otolaryngology of the University of Tokyo Hospital between 2008 and 2018. The proportion and timing of onset events between MSA-C and MSA-P and risks of onset were compared using chi-square tests and Cox proportional hazard models adjusted for age, sex, and disease severity, respectively.
resultsWe identified 113 patients (median age: 60 years, 72 men [64%]). The frequency and timing of VFMI, SA, MV, dysphagia, and surgeries were 55 patients (49%) and 76 (95% CI 61-91) months after MSA onset, 85 (75%) and 41 (32-50), 36 (32%) and 100 (73-127), 77 (68%) and 43 (36-50), and 25 (22%) and 102 (84-120), respectively. Twenty-seven patients (24%) had MSA-P and higher risk of VFMI (
conclusionWhile MSA-P is less common, it may involve heightened risk of VFMI and dysphagia early onset. Thus, careful follow-up for VFMI, SA, and dysphagia may be needed for these patients. CRITERIA FOR RATING DIAGNOSTIC ACCURACY STUDIES: Class II.
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