Evidence map›Paper›PMID 34316603›Full record

ReviewClinical parkinsonism & related disorders2019

Corticobasal degeneration and corticobasal syndrome: A review.

Vasilios C Constantinides, George P Paraskevas, Panagiotis G Paraskevas, Leonidas Stefanis, Elisabeth Kapaki

Abstract readReview
In one paragraph

Review in Clinical parkinsonism & related disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Limb apraxia in Parkinson's disease and atypical parkinsonian syndromes: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Prognostic factors of survival in corticobasal syndrome and corticobasal degeneration: A scoping review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Cells · 2026
    Article
  12. Article
  13. Observational
  14. Early-Onset Parkinson's Disease: Unique Features and Management Approaches.Current neurology and neuroscience reports · 2025
    Review
  15. Article
  16. Developing a novel reference region for [European journal of nuclear medicine and molecular imaging · 2025
    Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vasilios C Constantinides1st Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, Eginition Hospital, Greece.
George P Paraskevas1st Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, Eginition Hospital, Greece.
Panagiotis G ParaskevasDepartment of Nursing, Technological Educational Institute of Crete, School of Health and Welfare Services, Greece.
Leonidas Stefanis1st Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, Eginition Hospital, Greece.
Elisabeth Kapaki1st Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, Eginition Hospital, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Corticobasal degeneration (CBD) is a rare neurodegenerative disorder. The most common presentation of CBD is the corticobasal syndrome (CBS), which is a constellation of cortical and extrapyramidal symptoms and signs. Clinical-pathological studies have illustrated that CBD can present with diverse clinical phenotypes, including a non-fluent, agrammatic primary progressive aphasia syndrome, a behavioral, dysexecutive and visuospatial syndrome, as well as a progressive supranuclear palsy-like syndrome. Conversely, multiple pathologies, such as CBD, Alzheimer's disease and progressive supranuclear palsy may underlie a patient with CBS. This clinical-pathological overlap emphasizes the need for biomarkers that will assist in the accurate diagnosis of patients with CBS. This review presents an overview of the pathological, genetic, clinical and therapeutic characteristics of CBD, with an emphasis on the imaging (structural and functional) and biochemical (cerebrospinal fluid) biomarkers of CBD.

Indexed as

BiomarkersCerebrospinal fluidCorticobasal degenerationCorticobasal syndromeMRIPETSpect

Identifiers

PMID34316603
PMCPMC8288513

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.