Evidence map›Paper›PMID 34316424›Full record

ArticleThe mental health clinician2021

Loxapine in patient with clozapine-resistant psychosis.

Jennifer Erley, Sarah Goldsborough, Amy VandenBerg, Alexandra Audu

Open access · goldAbstract readCase Reports
In one paragraph

Article in The mental health clinician, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jennifer ErleyPsychiatry Pharmacy Resident, Michigan Medicine & University of Michigan College of Pharmacy, Ann Arbor, Michigan.ORCID https://orcid.org/0000-0002-5385-7521
Sarah GoldsboroughPsychiatry Pharmacy Resident, Michigan Medicine & University of Michigan College of Pharmacy, Ann Arbor, Michigan.ORCID https://orcid.org/0000-0002-3356-0106
Amy VandenBergPsychiatry Pharmacy Specialist, Michigan Medicine & University of Michigan College of Pharmacy, Ann Arbor, Michigan.ORCID https://orcid.org/0000-0002-2294-2694
Alexandra AuduPsychiatry Resident, Michigan Medicine, Ann Arbor, Michigan.ORCID https://orcid.org/0000-0002-9582-6766
Michigan Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clozapine is recognized as the drug of choice for treatment-refractory schizophrenia, but use may be limited because of strict monitoring requirements and adverse effects including severe neutropenia, seizures, and myocarditis. Loxapine is a first-generation antipsychotic with similarities to clozapine in both structure and receptor binding. This case describes a 57-year-old male with a history of severe paranoid schizophrenia despite treatment with clozapine and other psychotropic agents, who experienced clinical improvement after a cross titration from clozapine to loxapine. Loxapine may be a reasonable alternative in patients with treatment-refractory schizophrenia who do not tolerate or respond to clozapine.

Indexed as

antipsychotic agentsclozapineloxapineschizophrenia

Identifiers

PMID34316424
PMCPMC8287867
OpenAlexW3185944586

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.