Evidence map›Paper›PMID 34316365›Full record

ArticleF1000Research2020

The effects of the glycaemic control on the severity of the delirium in the advanced phase of Alzheimer's disease.

Antonio Martocchia, Marta Scarienzi, Pietro Prunas, Enrico Bentivegna, Mauro Cacciafesta, Paolo Martelletti, Giorgio Sesti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in F1000Research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Antonio MartocchiaSapienza University of Rome, ROMA CAPITALE, RM, 00100, Italy.
Marta ScarienziSapienza University of Rome, ROMA CAPITALE, RM, 00100, Italy.
Pietro PrunasSapienza University of Rome, ROMA CAPITALE, RM, 00100, Italy.
Enrico BentivegnaSapienza University of Rome, ROMA CAPITALE, RM, 00100, Italy.
Mauro CacciafestaDepartment of Cardiovascular, Respiratory, Nephrological, Anesthesiological and Geriatric Sciences, Sapienza University of Rome, Rome, Italy.
Paolo MartellettiSapienza University of Rome, ROMA CAPITALE, RM, 00100, Italy.ORCID 0000-0002-6556-4128
Giorgio SestiSapienza University of Rome, ROMA CAPITALE, RM, 00100, Italy.ORCID 0000-0002-1618-7688

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBehavioral and psychological symptoms of dementia (BPSD) and delirium are common in advanced phases of Alzheimer's disease (AD).

methodsThirty-eight moderate-severe AD patients were enrolled (n=16 affected by type 2 diabetes). Each patient received a comprehensive geriatric assessment (CGA) (including evaluation of BPSD and frailty), and a complete metabolic evaluation (including the measurement of the glycated hemoglobin, HbA1c).

resultsBoth the hyper- and hypo-glycemic extremes of the glycemic spectrum worsened BPSD, but delirium was more susceptible to hypoglycemic events. The severity of delirium was significantly related to cognitive function (r = -0.585, p<0.001) and frailty (r = +0.440, p<0.05).

conclusionsThe measurement of HbA1c was useful for evaluating the risk of delirium in relationship to glycemic control and nutritional status.

Indexed as

Alzheimer DiseaseDeliriumDiabetes Mellitus, Type 2AgedGlycemic ControlHumansAlzheimer’s diseasedeliriumglycaemic controlMarigliano-Cacciafesta-polypathology-scale

Identifiers

PMID34316365
PMCPMC8278245.2

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.