ArticleProceedings of meetings on acoustics. Acoustical Society of America2019
Histotripsy in collagenous tendons.
Article in Proceedings of meetings on acoustics. Acoustical Society of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Monitoring Fractionation in Elastic Tissues Using High Frame-Rate Doppler Ultrasound.Ultrasound in medicine & biology · 2025Article
- Acoustic Cavitation Emissions Predict Near-complete/complete Histotripsy Treatment in Soft Tissues.Ultrasound in medicine & biology · 2025Article
- Focused ultrasound as an alternative to dry needling for the treatment of tendinopathies: A murine model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Insights fromInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2024Review
- Dual-frequency boiling histotripsy in an ex vivo bovine tendinopathy model.The Journal of the Acoustical Society of America · 2023Article
- High intensity focused ultrasound atomization and erosion in healthy and tendinopathic tendons.Physics in medicine and biology · 2023Article
- Effects of focused ultrasound and dry needling on tendon mechanical properties.Journal of biomechanics · 2022Article
- Focused Ultrasound Mechanical Disruption of Ex Vivo Rat Tendon.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Tendon injuries comprise 45% of the 66 million musculoskeletal injuries each year with annual costs of $114 billion. Conservative therapies to treat injured tendon produce mixed success rates. Histotripsy is a high intensity focused ultrasound modality that creates and oscillates bubbles to fractionate soft tissues in a well-defined focal volume; however, highly collagenous tissues like tendon have proven resistant to histotripsy. The goal here is to explore acoustic parameters for mechanical fractionation of tendons. Large animal Achilles tendons were exposed to HIFU at 1.07-3.68 MHz with 0.005-20 ms pulses repeated at 1-1000 Hz for 15-60 s with acoustic pressures up to p+ = 97 MPa, p- = 27 MPa. A Verasonics research ultrasound imaging system and ATL L7-4 transducer was used to monitor bubble activity during exposure. Tendon samples were fixated and stained with Hematoxylin and Eosin (H&E) for cellular morphology analysis and alpha-nicotinamide dinucleotide diaphorase (αNADH-d) for enzymatic activity analysis. Results showed successful bubble creation in the focal region; however, only 1/90 samples showed focal coagulative necrosis histologically. Future work involves an evaluation of whether bubbles are of insufficient size or collapse strength to mechanically fractionate tendon. [Work supported by Penn State Seed Grant, NIH EB027886, and NSF DGE1255832].
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.