Evidence map›Paper›PMID 34316146›Full record

ArticleIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine2021

Epidemiology and Prognostic Utility of Cellular Components of Hematological System in Sepsis.

Harsha Sinha, Souvik Maitra, Rahul K Anand, Richa Aggarwal, Vimi Rewari, Rajeshwari Subramaniam, Anjan Trikha, Mahesh K Arora, Ravinder K Batra, Renu Saxena and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. IL-18-associated basophil and mast cell activation in sepsis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
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  11. Effect of Early Administration of Vitamin D on Clinical Outcome in Critically Ill Sepsis Patients: A Randomized Placebo-controlled Trial.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Harsha SinhaDepartment of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India.ORCID https://orcid.org/0000-0002-1938-1785
Souvik MaitraDepartment of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India.ORCID https://orcid.org/0000-0002-2328-9201
Rahul K AnandDepartment of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India.ORCID https://orcid.org/0000-0002-7852-1231
Richa AggarwalDepartment of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India.ORCID https://orcid.org/0000-0002-4531-2759
Vimi RewariDepartment of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India.ORCID https://orcid.org/0000-0001-9800-1367
Rajeshwari SubramaniamDepartment of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India.ORCID https://orcid.org/0000-0002-3830-5278
Anjan TrikhaDepartment of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India.ORCID https://orcid.org/0000-0002-6001-8486
Mahesh K AroraDepartment of Anaesthesiology, Institute of Liver and Biliary Sciences, New Delhi, India; Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India.ORCID https://orcid.org/0000-0002-1751-5006
Ravinder K BatraDepartment of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India.ORCID https://orcid.org/0000-0001-8879-0171
Renu SaxenaDepartment of Hematopathology, Medanta: The Medicity, Gurugram, Haryana, India; Department of Hematology, All India Institute of Medical Sciences, New Delhi, India.ORCID https://orcid.org/0000-0003-1532-297X
Dalim K BaidyaDepartment of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India.ORCID https://orcid.org/0000-0001-7811-7039
All India Institute of Medical Sciences · INMedanta The Medicity · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundData are lacking on the role of cellular components of hematological system as biomarkers for prognosis of sepsis. We planned to identify if these parameters measured at admission to ICU and at 72 hours can be useful as prognostic marker in septic critically ill patients. MATERIALS AND

methodsIn this prospective observational study, 130 adult patients with sepsis were recruited. Various hematological study parameters (total, differential, and absolute leukocyte count, platelet count, platelet distribution width, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio) were noted at day 1 and day 3 of admission. Primary outcome was 28-day mortality, and secondary outcomes were duration of mechanical ventilation, vasopressor requirement, ICU length of stay, and requirement of renal replacement therapy. The variables were compared between two groups and using binary regression model and were evaluated as prognostic markers for 28-day mortality.

resultsData from

conclusionThrombocytopenia on day 1 and eosinopenia on day 3 may predict 28-day mortality in sepsis. HOW TO CITE THIS ARTICLE: Sinha H, Maitra S, Anand RK, Aggarwal R, Rewari V, Subramaniam R,

Indexed as

Critically ill adultsMortality predictionSepsisThrombocytopenia

Identifiers

PMID34316146
PMCPMC8286394
OpenAlexW3167822519

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.