Evidence map›Paper›PMID 34316031›Full record

ArticleActa pharmacologica Sinica2022

Repeated cocaine administration upregulates CB

Hai-Ying Zhang, Lindsay De Biase, Ramesh Chandra, Hui Shen, Qing-Rong Liu, Eliot Gardner, Mary Kay Lobo, Zheng-Xiong Xi

Open access · bronzeAbstract read
In one paragraph

Article in Acta pharmacologica Sinica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

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  14. Receptor mechanisms underlying the CNS effects of cannabinoids: CBAdvances in pharmacology (San Diego, Calif.) · 2022
    Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Hai-Ying ZhangIntramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA. haiying.zhang@nih.gov.
Lindsay De BiaseDepartment of Physiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.
Ramesh ChandraDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Hui ShenIntramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Qing-Rong LiuLaboratory of Clinical Investigation, Intramural Research Program, National Institute on Aging, Baltimore, MD, USA.
Eliot GardnerIntramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Mary Kay LoboDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Zheng-Xiong XiIntramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA. zxi@intra.nida.nih.gov.
National Institute on Drug Abuse · USUniversity of Maryland, Baltimore · USNational Institute on Aging · USUniversity of California, Los Angeles · US

Funding

Basic brain mechanisms underlying drug addiction, craving, and relapseZIADA000478 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI GARDNER, ELIOT · 2009 to 2023
$7.9M
Cocaine-induced mitochondrial mechanisms and molecular mediators in reward circuitryR01DA038613 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LOBO, MARY KAY · 2014 to 2025
$4.9M
Cannabinoid CB1 and CB2 receptors and drug abuseZIGDA000633 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI XI, ZHENG-XIONG · 2020 to 2022
$3.6M
NIDA NIH HHS R01 DA038613
6 · The paper itself

Abstract

Cannabinoid CB

Indexed as

CocaineAnimalsDopamineDopaminergic NeuronsGene ExpressionMiceMice, Inbred C57BLMice, TransgenicNucleus AccumbensReceptors, Dopamine D1Receptors, Dopamine D2CocaineDopamineReceptors, Dopamine D1Receptors, Dopamine D2cannabinoidCB2 receptorcocaineD1-MSNsmicrogliaself-administration

Identifiers

PMID34316031
PMCPMC8975868
OpenAlexW3184527180

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.