Evidence map›Paper›PMID 34316014›Full record

ArticleNPJ precision oncology2021

Inter-eye genomic heterogeneity in bilateral retinoblastoma via aqueous humor liquid biopsy.

Elyssa Y Wong, Liya Xu, Lishuang Shen, Mary E Kim, Ashley Polski, Rishvanth K Prabakar, Rachana Shah, Rima Jubran, Jonathan W Kim, Jaclyn A Biegel and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ precision oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 citations in OpenAlex.

  1. Digital PCR Quantification of a CirculatingInternational journal of molecular sciences · 2026
    Article
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  6. Observational
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  15. Retinoblastoma: Aqueous humor liquid biopsy.Taiwan journal of ophthalmology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Elyssa Y Wong *The Vision Center, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Liya Xu *The Vision Center, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Lishuang ShenCenter for Personalized Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-0436-0199
Mary E KimThe Vision Center, Children's Hospital Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-7986-6119
Ashley PolskiThe Vision Center, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Rishvanth K PrabakarDepartment of Molecular and Computational Biology, University of Southern California, Los Angeles, CA, USA.
Rachana ShahCancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Rima JubranCancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Jonathan W KimThe Vision Center, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Jaclyn A BiegelCenter for Personalized Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Xiaowu GaiCenter for Personalized Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Peter KuhnDepartment of Biological Sciences, Dornsife College of Letters, Arts, and Sciences, University of Southern California, Los Angeles, CA, USA.
James HicksDepartment of Biological Sciences, Dornsife College of Letters, Arts, and Sciences, University of Southern California, Los Angeles, CA, USA.
Jesse L BerryThe Vision Center, Children's Hospital Los Angeles, Los Angeles, CA, USA. jesse.berry@med.usc.edu.ORCID http://orcid.org/0000-0002-8907-9100
University of Southern California · USChildren's Hospital of Los Angeles · US

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI William Dean Wallace · 1985 to 2026
$181.4M
Ophthalmic Therapeutics Engineering CoreP30EY029220 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Mahnaz Shahidi · 2018 to 2026
$6.5M
Development of a surrogate liquid biopsy from the aqueous humor in retinoblastoma eyes.K08CA232344 · NCI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI BERRY, JESSE L · 2018 to 2022
$1.1M
Hyundai Motor Group | Hyundai Motor America | Hyundai Hope On Wheels (Hope On Wheels) RGA012351NCI NIH HHS K08 CA232344NCI NIH HHS P30 CA014089NEI NIH HHS P30 EY029220U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) K08CA232344
6 · The paper itself

Abstract

Germline alterations in the RB1 tumor suppressor gene predispose patients to develop retinoblastoma (RB) in both eyes. While similar treatment is given for each eye, there is often a variable therapeutic response between the eyes. Herein, we use the aqueous humor (AH) liquid biopsy to evaluate the cell-free tumor DNA (ctDNA) from each eye in a patient with bilateral RB. Despite the same predisposing germline RB1 mutation, AH analysis identified a different somatic RB1 mutation as well as separate and distinct chromosomal alterations in each eye. The longitudinal alterations in tumor fraction (TFx) corresponded to therapeutic responses in each eye. This case demonstrates that bilateral RB tumors develop separate genomic alterations, which may play a role in tumorigenesis and prognosis for eye salvage. Identifying these inter-eye differences without the need for enucleated tumor tissue may help direct active management of RB, with particular usefulness in bilateral cases.

Identifiers

PMID34316014
PMCPMC8316348
OpenAlexW3178750295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.