Evidence map›Paper›PMID 34315938›Full record

ArticleScientific reports2021

Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort.

M A Salinero-Fort, F J San Andrés-Rebollo, J Cárdenas-Valladolid, M Méndez-Bailón, R M Chico-Moraleja, E Carrillo de Santa Pau, I Jiménez-Trujillo, I Gómez-Campelo, C de Burgos Lunar, J M de Miguel-Yanes and 1 more

Erratum issuedAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Methylome-wide studies of six metabolic traits.medRxiv : the preprint server for health sciences · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

M A Salinero-FortFundación de Investigación e Innovación Biosanitaria de Atención Primaria, Madrid, Spain.
F J San Andrés-RebolloFundación de Investigación e Innovación Biosanitaria de Atención Primaria, Madrid, Spain. fcojavier.san@salud.madrid.org.ORCID http://orcid.org/0000-0001-7843-1618
J Cárdenas-ValladolidFundación de Investigación e Innovación Biosanitaria de Atención Primaria, Madrid, Spain.
M Méndez-BailónDepartamento de Medicina Interna, Hospital Universitario Clínico San Carlos, Facultad de Medicina, Universidad Complutense de Madrid (UCM), Instituto de Investigación Sanitaria Hospital Clínico de San Carlos (IdISSC), Madrid, Spain.
R M Chico-MoralejaHospital Central de la Defensa, Madrid, Spain.
E Carrillo de Santa PauComputational Biology Group, Precision Nutrition and Cancer Program, IMDEA Food Institute, Madrid, Spain.
I Jiménez-TrujilloUnidad Docente y de Investigación en Medicina Preventiva y Salud Pública, Facultad de Ciencias de La Salud, Universidad Rey Juan Carlos, Alcorcón, Madrid, Spain.
I Gómez-CampeloInstituto de Investigación Sanitaria del Hospital Universitario la Paz (IdIPAZ), Madrid, Spain.
C de Burgos LunarDepartamento de Medicina Preventiva del Hospital Clínico de San Carlos, Instituto de Investigación Sanitaria Hospital Clínico de San Carlos (IdISSC), Madrid, Spain.
J M de Miguel-YanesDepartamento de Medicina Interna, Hospital General Universitario Gregorio Marañón. Facultad de Medicina, Universidad Complutense de Madrid (UCM), Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
MADIABETES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to develop two models to estimate first AMI and stroke/TIA, respectively, in type 2 diabetes mellitus patients, by applying backward elimination to the following variables: age, sex, duration of diabetes, smoking, BMI, and use of antihyperglycemic drugs, statins, and aspirin. As time-varying covariates, we analyzed blood pressure, albuminuria, lipid profile, HbA1c, retinopathy, neuropathy, and atrial fibrillation (only in stroke/TIA model). Both models were stratified by antihypertensive drugs. We evaluated 2980 patients (52.8% women; 67.3 ± 11.2 years) with 24,159 person-years of follow-up. We recorded 114 cases of AMI and 185 cases of stroke/TIA. The factors that were independently associated with first AMI were age (≥ 75 years vs. < 75 years) (p = 0.019), higher HbA1c (> 64 mmol/mol vs. < 53 mmol/mol) (p = 0.003), HDL-cholesterol (0.90-1.81 mmol/L vs. < 0.90 mmol/L) (p = 0.002), and diastolic blood pressure (65-85 mmHg vs. < 65 mmHg) (p < 0.001). The factors that were independently associated with first stroke/TIA were age (≥ 75 years vs. < 60 years) (p < 0.001), atrial fibrillation (first year after the diagnosis vs. more than one year) (p = 0.001), glomerular filtration rate (per each 15 mL/min/1.73 m

Indexed as

AgedDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionRisk FactorsStroke

Identifiers

PMID34315938
PMCPMC8316319

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.