Evidence map›Paper›PMID 34315890›Full record

ArticleNPJ breast cancer2021

Treatment-related amenorrhea in a modern, prospective cohort study of young women with breast cancer.

Philip D Poorvu, Jiani Hu, Yue Zheng, Shari I Gelber, Kathryn J Ruddy, Rulla M Tamimi, Jeffrey M Peppercorn, Lidia Schapira, Virginia F Borges, Steven E Come and 4 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ breast cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01468246 (Helping Ourselves, Helping Others), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01468246 active not recruitingnot on this map

Helping Ourselves, Helping Others: The Young Women's Breast Cancer Study

TypeobservationalSponsorDana-Farber Cancer InstituteRan2006 to 2035Enrolled1,302ConditionsBreast Cancer
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 3 countries.

Philip D PoorvuDana-Farber Cancer Institute, Boston, MA, USA.
Jiani HuDana-Farber Cancer Institute, Boston, MA, USA.
Yue ZhengDana-Farber Cancer Institute, Boston, MA, USA.
Shari I GelberDana-Farber Cancer Institute, Boston, MA, USA.
Kathryn J RuddyMayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-6298-332X
Rulla M TamimiWeill Cornell Medicine, New York, NY, USA.
Jeffrey M PeppercornMassachusetts General Hospital, Boston, MA, USA.
Lidia SchapiraStanford University, Palo Alto, CA, USA.
Virginia F BorgesUniversity of Colorado Cancer Center, Aurora, CO, USA.ORCID http://orcid.org/0000-0003-1158-7524
Steven E ComeBeth Israel Deaconess Medical Center, Boston, MA, USA.
Ellen WarnerSunnybrook Health Sciences Centre, Toronto, ON, Canada.
Matteo LambertiniUniversity of Genova, Genova, Italy.ORCID http://orcid.org/0000-0003-1797-5296
Shoshana M RosenbergDana-Farber Cancer Institute, Boston, MA, USA.
Ann H PartridgeDana-Farber Cancer Institute, Boston, MA, USA. ann_partridge@dfci.harvard.edu.ORCID http://orcid.org/0000-0002-4722-4824
Dana-Farber Cancer Institute · USBeth Israel Deaconess Medical Center · USCornell University · USMassachusetts General Hospital · USMayo Clinic in Arizona · USOspedale Policlinico San Martino · ITPalo Alto University · USSunnybrook Health Science Centre · CAUniversity of Colorado Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Young women with breast cancer experience unique treatment and survivorship issues centering on treatment-related amenorrhea (TRA), including fertility preservation and management of ovarian function as endocrine therapy. The Young Women's Breast Cancer Study (YWS) is a multi-center, prospective cohort study of women diagnosed at age ≤40, enrolled from 2006 to 2016. Menstrual outcomes were self-reported on serial surveys. We evaluated factors associated with TRA using logistic regression. One year post-diagnosis, 286/789 (36.2%) experienced TRA, yet most resumed menses (2-year TRA: 120/699; 17.2%). Features associated with 1-year TRA included older age (OR

Identifiers

PMID34315890
PMCPMC8316568
OpenAlexW3184508197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.