ArticleNature communications2021
The trans-omics landscape of COVID-19.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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82citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
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Who cites it
82 citing papers in PubMed, 133 citations in OpenAlex.
- Alteration of the Gut-Lung Axis After Severe COVID-19 Infection and Modulation Through Probiotics: A Randomized, Controlled Pilot Study.Nutrients · 2024Trial
- Effects of l-Arginine Plus Vitamin C Supplementation on l-Arginine Metabolism in Adults with Long COVID: Secondary Analysis of a Randomized Clinical Trial.International journal of molecular sciences · 2023Trial
- Network-based integration of metabolomics data from large-scale repositories.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Article
- Review
- Monocyte chemoattractant protein-1 (MCP-1/CCL2) and matrix metalloproteinase-9 (MMP-9) as biomarkers of disease severity in COVID-19 patients.Biochemistry and biophysics reports · 2026Article
- COVID-19 multi-omics reveal organ-specific responses and biomarkers.Journal of translational medicine · 2026Article
- Scalable randomized kernel methods for multiview data integration and prediction with application to Coronavirus disease.Biostatistics (Oxford, England) · 2025Article
- Utility of plasma MicroRNA profiling as diagnostic biomarker in immune system activation and inflammation and early predictor of severity in patients with COVID-19.Scientific reports · 2025Article
- Altered brain tissue microstructure and neurochemical profiles in long COVID and recovered COVID-19 individuals: A multimodal MRI study.Brain, behavior, & immunity - health · 2025Article
- Effect of the gut microbiota-derived tryptophan metabolite indole-3-acetic acid in pneumonia.Nature communications · 2025Observational
- Genes Encoding Heat Shock Proteins Are Associated with Risk and Clinical Course of Severe COVID-19: A Pilot Study.International journal of molecular sciences · 2025Article
- Cytokines from Macrophages Activated by Spike S1 of SARS-CoV-2 Cause eNOS/Arginase Imbalance in Endothelial Cells.International journal of molecular sciences · 2025Article
- Telomere Length, Oxidative Stress Markers, and Related miRNAs in Non-Invasive Samples of Mild COVID-19 Cases.International journal of molecular sciences · 2025Article
- Enhanced Production of Lipid Mediators in Plasma and Activation of DNA Damage Pathways in PBMCs Are Correlated With the Severity of Ancestral SARS-CoV-2 Infection.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Landscape of chimeric RNAs in COVID-19 patient blood.Genes & diseases · 2025Article
- The roles of arginases and arginine in immunity.Nature reviews. Immunology · 2025Review
- Recent advances in nutritional metabolism studies on SARS-CoV-2 infection.Infectious medicine · 2025Review
- SARS-CoV-2 variants induce increased inflammatory gene expression but reduced interferon responses and heme synthesis as compared with wild type strains.Scientific reports · 2024Article
- An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms.Nature immunology · 2024Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
70 authors at 10 institutions in 4 countries.
Peng Wu *Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Dongsheng Chen *BGI-Shenzhen, Shenzhen, China.
Wencheng Ding *Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Ping Wu *Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Hongyan Hou *Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yong Bai *BGI-Shenzhen, Shenzhen, China.ORCID 0000-0001-5960-8000
Yuwen Zhou *BGI-Shenzhen, Shenzhen, China.
Kezhen Li *Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0001-7943-5389
Shunian XiangBGI-Shenzhen, Shenzhen, China.
Panhong LiuBGI-Shenzhen, Shenzhen, China.ORCID 0000-0003-4568-3119
Jia JuBGI-Shenzhen, Shenzhen, China.
Ensong GuoCancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0002-7388-4324
Jia LiuCancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Bin YangCancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0002-6218-2773
Junpeng FanCancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0002-9413-408X
Liang HeCancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Ziyong SunDepartment of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Ling FengDepartment of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Jian WangDepartment of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Tangchun WuDepartment of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hao WangDepartment of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jin ChengDepartment of Research, Xiangyang Central Hospital, Hubei University of Arts and Science, Xiangyang, Hubei, China.
Hui XingDepartment of Obstetrics and Gynecology, Xiangyang Central Hospital, Hubei University of Arts and Science, Xiangyang, Hubei, China.
Yifan MengDepartment of Gynecologic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China.
Yongsheng LiKey Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China.
Yuanliang ZhangBGI-Shenzhen, Shenzhen, China.
Hongbo LuoBGI-Shenzhen, Shenzhen, China.
Gang XieBGI-Shenzhen, Shenzhen, China.
Xianmei LanBGI-Shenzhen, Shenzhen, China.
Ye TaoBGI-Shenzhen, Shenzhen, China.
Jiafeng LiBGI-Shenzhen, Shenzhen, China.
Hao YuanBGI-Shenzhen, Shenzhen, China.
Kang HuangBGI-Shenzhen, Shenzhen, China.
Wan SunBGI-Shenzhen, Shenzhen, China.ORCID 0000-0002-0347-2519
Xiaobo QianBGI-Shenzhen, Shenzhen, China.
Zhichao LiBGI-Shenzhen, Shenzhen, China.
Mingxi HuangBGI-Shenzhen, Shenzhen, China.
Peiwen DingBGI-Shenzhen, Shenzhen, China.
Haoyu WangBGI-Shenzhen, Shenzhen, China.
Jiaying QiuBGI-Shenzhen, Shenzhen, China.
Feiyue WangBGI-Shenzhen, Shenzhen, China.
Shiyou WangBGI-Shenzhen, Shenzhen, China.ORCID 0000-0003-1901-3920
Jiacheng ZhuBGI-Shenzhen, Shenzhen, China.
Xiangning DingBGI-Shenzhen, Shenzhen, China.
Chaochao ChaiBGI-Shenzhen, Shenzhen, China.
Langchao LiangBGI-Shenzhen, Shenzhen, China.
Xiaoling WangBGI-Shenzhen, Shenzhen, China.
Lihua LuoBGI-Shenzhen, Shenzhen, China.
Yuzhe SunBGI-Shenzhen, Shenzhen, China.
Ying YangBGI-Shenzhen, Shenzhen, China.ORCID 0000-0003-4843-1689
Zhenkun ZhuangBGI-Shenzhen, Shenzhen, China.
Tao LiBGI-Shenzhen, Shenzhen, China.
Lei TianBGI-Shenzhen, Shenzhen, China.
Shaoqiao ZhangBGI-Hubei, BGI-Shenzhen, Wuhan, China.
Linnan ZhuBGI-Shenzhen, Shenzhen, China.
Ashley ChangBGI-Shenzhen, Shenzhen, China.
Lei ChenCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Yiquan WuHIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Xiaoyan MaDepartment of Biochemistry, University of Cambridge, Cambridge, UK.
Fang ChenBGI-Shenzhen, Shenzhen, China.
Yan RenBGI-Shenzhen, Shenzhen, China.ORCID 0000-0002-4007-8625
Xun XuBGI-Shenzhen, Shenzhen, China.ORCID 0000-0002-5338-5173
Siqi LiuBGI-Shenzhen, Shenzhen, China.ORCID 0000-0001-9744-3681
Jian WangBGI-Shenzhen, Shenzhen, China.
Huanming YangBGI-Shenzhen, Shenzhen, China.
Lin WangDepartment of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. lin_wang@hust.edu.cn.
Chaoyang SunCancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China. suncydoctor@gmail.com.ORCID 0000-0003-2469-1638
Ding MaCancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China. Dingma424@126.com.
Xin JinBGI-Shenzhen, Shenzhen, China. jinxin@genomics.cn.
Gang ChenCancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China. tjchengang@hust.edu.cn.
BGI Group (China) · CNTongji Hospital · CNHubei University of Arts and Science · CNHainan Medical University · CNHuazhong University of Science and Technology · CNNational Institutes of Health · USSun Yat-sen University · CNUniversity of Cambridge · GBWuhan Union Hospital · CNYangzhou University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 231 COVID-19 patients, prefiltered to exclude those with selected comorbidities, yet with symptoms ranging from asymptomatic to critically ill. Using integrative analysis of genomic, transcriptomic, proteomic, metabolomic and lipidomic profiles, we report a trans-omics landscape for COVID-19. Our analyses find neutrophils heterogeneity between asymptomatic and critically ill patients. Meanwhile, neutrophils over-activation, arginine depletion and tryptophan metabolites accumulation correlate with T cell dysfunction in critical patients. Our multi-omics data and characterization of peripheral blood from COVID-19 patients may thus help provide clues regarding pathophysiology of and potential therapeutic strategies for COVID-19.
Indexed as
COVID-19Critical IllnessGenomicsHumansLipidomicsMetabolomicsNeutrophilsTranscriptome
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