Evidence map›Paper›PMID 34315853›Full record

ArticleCell death & disease2021

The m6A mRNA demethylase FTO in granulosa cells retards FOS-dependent ovarian aging.

Zhong-Xin Jiang, Yi-Ning Wang, Zi-Yuan Li, Zhi-Hui Dai, Yi He, Kun Chu, Jia-Yi Gu, Yi-Xuan Ji, Ning-Xia Sun, Fu Yang and 1 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 112 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. FTO-mediated NR1D1 mScientific reports · 2026
    Article
  9. mCellular & molecular biology letters · 2026
    Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. The role of mGenes & diseases · 2026
    Review
  19. Review
  20. Review

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Zhong-Xin Jiang *Center for Reproductive Medicine & Fertility Preservation program, International Peace maternity and Child health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China.ORCID http://orcid.org/0000-0002-9307-6498
Yi-Ning Wang *The Center of Reproductive Medicine, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Zi-Yuan Li *The Center of Reproductive Medicine, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Zhi-Hui Dai *The Department of Medical Genetics, Naval Medical University, Shanghai, 200433, China.
Yi HeThe Center of Reproductive Medicine, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Kun ChuThe Center of Reproductive Medicine, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Jia-Yi GuThe Center of Reproductive Medicine, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Yi-Xuan JiThe Center of Reproductive Medicine, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Ning-Xia SunThe Center of Reproductive Medicine, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, China. suesunchzh@126.com.
Fu YangThe Department of Medical Genetics, Naval Medical University, Shanghai, 200433, China. yangfusq1997@smmu.edu.cn.
Wen LiCenter for Reproductive Medicine & Fertility Preservation program, International Peace maternity and Child health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China. liwen@smmu.edu.cn.
Shanghai Changzheng Hospital · CNShanghai Jiao Tong University · CNShanghai Medical College of Fudan University · CN

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81873821National Natural Science Foundation of China (National Science Foundation of China) 82071605
6 · The paper itself

Abstract

Multifunctional N6-methyladenosine (m6A) has been revealed to be an important epigenetic component in various physiological and pathological processes, but its role in female ovarian aging remains unclear. Thus, we demonstrated m6A demethylase FTO downregulation and the ensuing increased m6A in granulosa cells (GCs) of human aged ovaries, while FTO-knockdown GCs showed faster aging-related phenotypes mediated. Using the m6A-RNA-sequence technique (m6A-seq), increased m6A was found in the FOS-mRNA-3'UTR, which is suggested to be an erasing target of FTO that slows the degradation of FOS-mRNA to upregulate FOS expression in GCs, eventually resulting in GC-mediated ovarian aging. FTO acts as a senescence-retarding protein via m6A, and FOS knockdown significantly alleviates the aging of FTO-knockdown GCs. Altogether, the abovementioned results indicate that FTO in GCs retards FOS-dependent ovarian aging, which is a potential diagnostic and therapeutic target against ovarian aging and age-related reproductive diseases.

Indexed as

3' Untranslated RegionsAdenosineAgingAlpha-Ketoglutarate-Dependent Dioxygenase FTOCase-Control StudiesCell LineDown-RegulationFemaleGene SilencingGranulosa CellsHumansMethylationModels, BiologicalOvaryProto-Oncogene Proteins c-fosReactive Oxygen Species3' Untranslated RegionsAdenosineAlpha-Ketoglutarate-Dependent Dioxygenase FTOFOS protein, humanFTO protein, humanN-methyladenosineProto-Oncogene Proteins c-fosReactive Oxygen SpeciesRNA, Messenger

Identifiers

PMID34315853
PMCPMC8316443
OpenAlexW3184485367

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.