Evidence map›Paper›PMID 34315815›Full record

ArticleRNA (New York, N.Y.)2021

SARS-CoV-2 infection triggers widespread host mRNA decay leading to an mRNA export block.

James M Burke, Laura A St Clair, Rushika Perera, Roy Parker

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 99 citations in OpenAlex.

  1. Article
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  6. SARS-CoV-2 and MERS-CoV disrupt host protein synthesis via nsp1 with differential effects on the integrated stress response.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  11. Review
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  15. Article
  16. Article
  17. Structure-function mapping and mechanistic insights on the SARS CoV2 Nsp1.Protein science : a publication of the Protein Society · 2024
    Article
  18. SARS-CoV2 Nsp1 is a metal-dependent DNA and RNA endonuclease.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024
    Article
  19. Review
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

James M BurkeDepartment of Biochemistry, University of Colorado Boulder, Boulder, Colorado 80303, USA.
Laura A St ClairCenter for Vector-Borne and Infectious Diseases, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA.
Rushika PereraCenter for Vector-Borne and Infectious Diseases, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA.
Roy ParkerDepartment of Biochemistry, University of Colorado Boulder, Boulder, Colorado 80303, USA.
Colorado State University · USHoward Hughes Medical Institute · USUniversity of Colorado Boulder · US

Funding

Determining the specificity and biological functions of widespread host mRNA degradation by RNase LF32AI145112 · NIAID · UNIVERSITY OF COLORADO · PI BURKE, JAMES M · 2019 to 2021
$200k
Howard Hughes Medical InstituteNIAID NIH HHS F32 AI145112
6 · The paper itself

Abstract

The transcriptional induction of

Indexed as

RNA StabilityA549 CellsAngiotensin-Converting Enzyme 2Cell LineCOVID-19EndoribonucleasesHost-Pathogen InteractionsHumansIn Situ Hybridization, FluorescenceInterferon Regulatory Factor-3InterferonsRNA, MessengerSARS-CoV-2Single Molecule ImagingViral Nonstructural Proteins2-5A-dependent ribonucleaseACE2 protein, humanAngiotensin-Converting Enzyme 2EndoribonucleasesInterferon Regulatory Factor-3InterferonsIRF3 protein, humanORF1ab polyprotein, SARS-CoV-2RNA, MessengerViral Nonstructural Proteinsinnate immunityinterferonIRF3mRNA decaymRNA exportRNase LSARS-CoV-2

Identifiers

PMID34315815
PMCPMC8522697
OpenAlexW3186354235

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.