ArticleJournal of neurointerventional surgery2022
Carotid webs produce greater hemodynamic disturbances than atherosclerotic disease: a DSA time-density curve study.
Article in Journal of neurointerventional surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Recurrent Large-Vessel Occlusion Associated With Flow Disturbance in a Carotid Web.Journal of clinical neurology (Seoul, Korea) · 2026Article
- Safety and efficacy of staged bilateral carotid artery stenting for bilateral carotid webs.Journal of cerebrovascular and endovascular neurosurgery · 2026Article
- Recurrent ischemic stroke caused by a carotid web: a case report.Journal of medical case reports · 2026Article
- A case of carotid web with thrombosis causing stroke in a young adult.BMC neurology · 2026Article
- Silent Threats: Asymptomatic Re-Thrombosis in Carotid Web and the Window for Preventive Intervention.Neurointervention · 2025Article
- Intima-Media Thickening with Carotid Webs: A Case Report of a Potentially High-Risk Association.Diagnostics (Basel, Switzerland) · 2025Article
- Operative Procedures for Ultrasound Assessment of Extracranial Artery Disease: A Narrative Review by the Italian Society for Vascular Investigation (SIDV).Journal of clinical medicine · 2025Review
- Status epilepticus of carotid web after carotid artery stenting: A case report.The Journal of international medical research · 2025Article
- Endovascular treatment of total internal carotid artery occlusion caused by a carotid web: a case description and literature analysis.Quantitative imaging in medicine and surgery · 2025Article
- Carotid Web: An Update Focusing on Its Relationship With Fibromuscular Dysplasia and Therapeutic Strategy.Journal of stroke · 2025Review
- Assessment of Complex Flow Patterns in Patients With Carotid Webs, Patients With Carotid Atherosclerosis, and Healthy Subjects Using 4D Flow MRI.Journal of magnetic resonance imaging : JMRI · 2024Article
- Subjects with carotid webs demonstrate pro-thrombotic hemodynamics compared to subjects with carotid atherosclerosis.Scientific reports · 2024Article
- The differences between carotid web and carotid web with plaque: based on multimodal ultrasonic and clinical characteristics.Insights into imaging · 2024Article
- Optimization of 4D Flow MRI Spatial and Temporal Resolution for Examining Complex Hemodynamics in the Carotid Artery Bifurcation.Cardiovascular engineering and technology · 2023Article
- Symptomatic atherosclerotic plaque accompanied by carotid web.The neuroradiology journal · 2023Article
- The carotid web: Current research status and imaging features.Frontiers in neuroscience · 2023Review
- The Value of Contrast-Enhanced Ultrasound in the Evaluation of Carotid Web.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCarotid webs (CaWs) are associated with ischemic strokes in younger patients without degrees of stenosis that are traditionally considered clinically significant.
objectiveTo compare the hemodynamic parameters in the internal carotid artery (ICA) bulbar segment in patients with CaW with those in patients with atherosclerotic lesions using time-density curve (TDC) analysis of digital subtraction angiography (DSA) images.
methodsWe retrospectively assessed DSA images of 47 carotid arteries in 41 adult patients who underwent ICA catheter angiography for evaluation after ischemic stroke. Hemodynamic parameters, including full width at half maximum (FWHM) and area under the time-density curve (AUC) as proxies for increased flow stasis, were calculated using TDC analyses of a region of interest (ROI) in the ICA bulb immediately rostral to the web/atherosclerotic plaque, relative to a standardized ROI in the ipsilateral distal common carotid artery (eg, relative FWHM (rFWHM)). Hemodynamic parameters were compared using non-parametric Kruskal-Wallis tests. Logistic regression was used to predict CaW versus mild/moderate atherosclerosis for each hemodynamic parameter, adjusting for degree of stenosis.
resultsMean age of patients was 56.0±13 years, with 22 (53.7%) women. 17 CaWs, 22 atherosclerotic plaques (15 mild/moderate and 7 severe), and eight normal carotid arteries were assessed. Significant between-group differences were present in the relative total AUC (p<0.001), relative AUC at wash out (p=0.031), and relative FWHM (p=0.001). Logistic regression to predict CaW versus mild/moderate atherosclerosis showed that rAUC total had the highest predictive value (pAUC=0.96, 95% CI 0.90 to 1.00), followed by rFWHM (0.87, 95% CI 0.74 to 1.00), and rAUC WO (0.74, 95% CI (0.57 to 0.91).
conclusionCaW results in larger local hemodynamic disruption, characterized by flow stasis, than mild/moderate carotid atherosclerotic lesions, suggesting that CaWs may produce larger regions of thrombogenic flow stasis.
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