Evidence map›Paper›PMID 34315730›Full record

Trial reportBMJ global health2021

Effect of peer-distributed HIV self-test kits on demand for biomedical HIV prevention in rural KwaZulu-Natal, South Africa: a three-armed cluster-randomised trial comparing social networks versus direct delivery.

Maryam Shahmanesh, T Nondumiso Mthiyane, Carina Herbsst, Melissa Neuman, Oluwafemi Adeagbo, Paul Mee, Natsayi Chimbindi, Theresa Smit, Nonhlanhla Okesola, Guy Harling and 9 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ global health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03751826 (Peer Delivery of HIV Self-Screening to Support Linkage to HIV Prevention in Rural KwaZulu-Natal, South Africa), which is not on this map. Cited by 31 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 5 pooled it
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03751826 naunknown statusnot on this map

Peer Delivery of HIV Self-Screening to Support Linkage to HIV Prevention in Rural KwaZulu-Natal, South Africa: A Cluster Randomized Control Trial

TypeinterventionalSponsorUniversity College, LondonRan2019 to 2019Enrolled2,000ConditionsHIVArmsIncentivised network delivery of HIV-ST, Peer navigator delivery of HIV-ST, standard of care
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 5 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 6 countries.

Maryam ShahmaneshInstitute for Global Health, University College London, London, UK m.shahmanesh@ucl.ac.uk.ORCID 0000-0001-7129-8535
T Nondumiso MthiyaneAfrica Health Research Institute, Durban, Kwa-Zulu Natal, South Africa.
Carina HerbsstAfrica Health Research Institute, Durban, Kwa-Zulu Natal, South Africa.
Melissa NeumanMRC International Statistics and Epidemiology Group, London School of Hygiene & Tropical Medicine, London, London, UK.ORCID 0000-0002-8870-6504
Oluwafemi AdeagboAfrica Health Research Institute, Durban, Kwa-Zulu Natal, South Africa.
Paul MeeLondon School of Hygiene and Tropical Medicine, Faculty of Epidemiology and Population Health, London, London, UK.
Natsayi ChimbindiAfrica Health Research Institute, Durban, Kwa-Zulu Natal, South Africa.
Theresa SmitAfrica Health Research Institute, Durban, Kwa-Zulu Natal, South Africa.
Nonhlanhla OkesolaAfrica Health Research Institute, Durban, Kwa-Zulu Natal, South Africa.
Guy HarlingInstitute for Global Health, University College London, London, UK.ORCID 0000-0001-6604-491X
Nuala McGrathAfrica Health Research Institute, Durban, Kwa-Zulu Natal, South Africa.
Lorraine SherrInstitute for Global Health, University College London, London, UK.
Janet SeeleyDepartment of Global Health &Development, London School of Hygiene and Tropical Medicine, London, UK.
Hasina SubedarSouth African National Department of Health, Pretoria, South Africa.
Cheryl JohnsonHIV, Hepatitis and STI Department, World Health Organisation, Geneva, Switzerland.ORCID 0000-0001-5499-5523
Karin HatzoldPopulation Services International, Washington, District of Columbia, USA.
Fern Terris-PrestholtDepartment of Global Health and Development, London School of Hygiene and Tropical Medicine, London, London, UK.
Frances M CowanCentre for Sexual Health HIV/AIDS Research (CeSHHAR) Zimbabwe, Harare, Zimbabwe.
Elizabeth Lucy CorbettDepartment of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.
Africa Health Research Institute · ZALondon School of Hygiene & Tropical Medicine · GBDepartment of Health · ZALiverpool School of Tropical Medicine · GBPopulation Services International · USUniversity College London · GBUniversity of Liverpool · GBWorld Health Organization · CH

Funding

Maximizing combination HIV prevention, uptake and retention by adolescent girls and young womenR01MH114560 · NIMH · KWAZULU-NATAL RESEARCH INSTITUTE TB-HIV · PI SHAHMANESH, MARYAM · 2017 to 2023
$2.0M
Department of Health RP-2017-08-ST2-008Medical Research Council MR/R010161/1NIMH NIH HHS R01 MH114560Wellcome TrustWellcome Trust 082384/Z/07/ZWorld Health Organization 001
6 · The paper itself

Abstract

STUDY

objectiveWe investigated two peer distribution models of HIV self-testing (HIVST) in HIV prevention demand creation compared with trained young community members (peer navigators).

methodsWe used restricted randomisation to allocate 24 peer navigator pairs (clusters) in KwaZulu-Natal 1:1:1: (1) standard of care (

resultsBetween March and December 2019, 4163 packs (1098 SOC, 1480 PND, 1585 IPN) were distributed across 24 clusters. During 144 pnm, 272 18-30 year olds linked to PrEP/ART (1.9/pnm). Linkage rates for 18-24-year-old women were lower for IPN (n=26, 0.54/pnm) than PND (n=45, 0.80/pnm; SOC n=49, 0.85/pnm). Rate ratios were 0.68 (95% CI 0.28 to 1.66) for IPN versus PND, 0.64 (95% CI 0.26 to 1.62) for IPN versus SOC and 0.95 (95% CI 0.38 to 2.36) for PND versus SOC. In 18-30 year olds, PND had significantly more linkages than IPN (2.11 vs 0.88/pnm, RR 0.42, 95% CI 0.18 to 0.98). Cost per pack distributed was cheapest for IPN (US$36) c.f. SOC (US$64). Cost per person linked to PrEP/ART was cheaper in both peer navigator arms compared with IPN. DISCUSSION: HIVST did not increase demand for PrEP/ART. Incentivised social network distribution reached large numbers with HIVST but resulted in fewer linkages compared with PrEP/ART promotion by peer navigators. TRIAL REGISTRATION NUMBER: NCT03751826.

Indexed as

HIV InfectionsSelf-TestingAdolescentAdultFemaleHumansRural PopulationSocial NetworkingSouth AfricaYoung Adultcluster randomized trialHIVother diagnostic or toolprevention strategiespublic health

Identifiers

PMID34315730
PMCPMC8317107
OpenAlexW3185727724

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.