ArticleUltrasound in medicine & biology2021
Clusters of Ultrasound Scattering Parameters for the Classification of Steatotic and Normal Livers.
Article in Ultrasound in medicine & biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Quantitative Multifrequency Ultrasound Imaging Using Narrowband Pulsing for Tissue Characterization.Investigative radiology · 2026Article
- Deep-learning-Assisted Photoacoustic and Ultrasound Evaluation for Pre-transplant Human Liver Graft Quality and Transplant Suitability.medRxiv : the preprint server for health sciences · 2026Article
- Multiparametric quantification and visualization of liver fat using ultrasound.WFUMB ultrasound open · 2024Article
- H-Scan Discrimination for Tumor Microenvironmental Heterogeneity in Melanoma.Ultrasound in medicine & biology · 2024Article
- Multiparametric ultrasound imaging for early-stage steatosis: Comparison with magnetic resonance imaging-based proton density fat fraction.Medical physics · 2024Article
- Simultaneous imaging of ultrasonic relative backscatter and attenuation coefficients for quantitative liver steatosis assessment.Scientific reports · 2023Article
- High-Resolution Ultrasound Characterization of Local Scattering in Cancer Tissue.Ultrasound in medicine & biology · 2023Article
- Improving breast cancer diagnosis by incorporating raw ultrasound parameters into machine learning.Machine learning: science and technology · 2022Article
- 3-D H-scan ultrasound imaging of relative scatterer size using a matrix array transducer and sparse random aperture compounding.Computers in biology and medicine · 2022Article
- Photoacoustic graphic equalization and application in characterization of red blood cell aggregates.Photoacoustics · 2022Article
- Disease-Specific Imaging Utilizing Support Vector Machine Classification of H-Scan Parameters: Assessment of Steatosis in a Rat Model.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- H-scan trajectories indicate the progression of specific diseases.Medical physics · 2021Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The study of ultrasound tissue interactions in fatty livers has a long history with strong clinical potential for assessing steatosis. Recently we proposed alternative measures of first- and second-order statistics of echoes from soft tissues, namely, the H-scan, which is based on a matched filter approach, to quantify scattering transfer functions and the Burr distribution to model speckle patterns. Taken together, these approaches produce a multiparameter set that is directly related to the fundamentals of ultrasound propagation in tissue. To apply this approach to the problem of assessing steatotic livers, these analyses were applied to in vivo rat livers (N=21) under normal feeding conditions or after receiving a methionine- and choline-deficient diet that produces steatosis within a few weeks. Ultrasound data were acquired at baseline and again at weeks 2 and 6 before applying the H-scan and Burr analyses. Furthermore, a classification technique known as the support vector machine was then used to find clusters of the five parameters that are characteristic of the different steatotic liver conditions as confirmed by histologic processing of excised liver tissue samples. With the in vivo multiparametric ultrasound measurement approach and determination of clusters, steatotic can be discriminated from normal livers with 100% accuracy in a rat animal model.
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