Evidence map›Paper›PMID 34315545›Full record

ArticleJournal of medical case reports2021

Rare paraneoplastic syndrome of prostatic cancer: limbic encephalitis: a case report.

Omar Karray, Sven Tolner, Naïm Yarak, Maguy Cherfan, Mihaela Dana Cosma, Walid Sleiman, Philippe Niclot, Jean Louis Dubost, Patrick Coloby, Stéphane Bart

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of medical case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Omar KarrayUrology Department, René Dubos Hospital, 6, Avenue de l'Ile-de-France, 95300, Pontoise, France. omar.karray@ght-novo.fr.
Sven TolnerNeurology Department, René Dubos Hospital, Pontoise, France.
Naïm YarakUrology Department, René Dubos Hospital, 6, Avenue de l'Ile-de-France, 95300, Pontoise, France.
Maguy CherfanPathology Department, René Dubos Hospital, Pontoise, France.
Mihaela Dana CosmaPathology Department, René Dubos Hospital, Pontoise, France.
Walid SleimanUrology Department, René Dubos Hospital, 6, Avenue de l'Ile-de-France, 95300, Pontoise, France.
Philippe NiclotNeurology Department, René Dubos Hospital, Pontoise, France.
Jean Louis DubostIntensive Care Unit, René Dubos Hospital, Pontoise, France.
Patrick ColobyUrology Department, René Dubos Hospital, 6, Avenue de l'Ile-de-France, 95300, Pontoise, France.
Stéphane BartUrology Department, René Dubos Hospital, 6, Avenue de l'Ile-de-France, 95300, Pontoise, France.
Centre Hospitalier René-Dubos · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLimbic encephalitis is an autoimmune neurologic disorder, often of paraneoplastic origin, that seldom complicates prostatic tumors. The nonspecificity of symptoms makes the diagnosis sometimes difficult to establish. Prognosis is essentially determined by comorbidities and sensorineural and cognitive sequelae. CLINICAL CASE: A 66-year-old Caucasian patient known to have prostatic small-cell neuroendocrine adenocarcinoma under hormonal therapy developed complex partial epileptic seizures associated with rapidly aggravating severe memory impairment. The tripod of autoimmune limbic encephalitis diagnosis was based on the clinical aspect of brain's functional deterioration, electroencephalography aspect, and γ-aminobutyric acid type B anti-receptor antibody positivity. Clinical, diagnostic, and therapeutic management as well as evolutionary risks were further analyzed.

conclusionLimbic encephalitis is an extremely rare presentation of neurologic paraneoplastic syndromes. A better knowledge of this entity would help better manage diagnostic and therapeutic difficulties and reduce the risk of possible sequelae.

Indexed as

Autoimmune DiseasesLimbic EncephalitisProstatic NeoplasmsAgedAutoantibodiesElectroencephalographyHumansMaleAutoantibodiesGABA receptorsLimbic encephalitisProstatic neoplasmsSeizures

Identifiers

PMID34315545
PMCPMC8317402
OpenAlexW3184551113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.