ArticleBMC anesthesiology2021
Pharmacokinetics and safety of liposomal bupivacaine after local infiltration in healthy Chinese adults: a phase 1 study.
Article in BMC anesthesiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04158102 (A Phase 1, Open Label Study to Evaluate the Pharmacokinetics and Safety of EXPAREL® Following Subcutaneous Administration in Healthy Chinese Subjects), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase 1, Open Label Study to Evaluate the Pharmacokinetics and Safety of EXPAREL® Following Subcutaneous Administration in Healthy Chinese Subjects
Who cites it
15 citing papers in PubMed, 14 citations in OpenAlex.
- Median effective concentration of liposomal bupivacaine for ultrasound-guided supra-inguinal fascia iliaca compartment block in older adults undergoing total hip arthroplasty: a dixon geometric up-and-down dose-finding study.BMC anesthesiology · 2026Trial
- Efficacy and safety of liposomal bupivacaine versus bupivacaine for retrolaminar block for postoperative analgesia in patients undergoing posterior lumbar interbody fusion: a randomized controlled trial.BMC anesthesiology · 2026Trial
- Efficacy of different nerve block techniques with liposomal bupivacaine for postoperative analgesia in patients undergoing single-port video-assisted thoracoscopic partial lung resection.Frontiers in medicine · 2026Trial
- Analgesic Efficacy of Continuous Bupivacaine Infusion versus Liposomal Bupivacaine in Parasacral Ischial Plane Block After Total Knee Arthroplasty: An Open-Label, Randomized, Controlled, Non-Inferiority Study.Drug design, development and therapy · 2026Trial
- Efficacy of bupivacaine liposome transversus abdominis plane block in enhancing postoperative recovery following laparoscopic colorectal cancer resection.Langenbeck's archives of surgery · 2025Trial
- The efficacy of liposomal bupivacaine in parasacral ischial plane block for pain management after total knee arthroplasty: a randomized controlled trial.Journal of orthopaedic surgery and research · 2025Trial
- The Analgesic Efficacy of Liposomal Bupivacaine in Adductor Canal Block Following Knee Arthroplasty: A Single-Center, Prospective, Randomized and Controlled Clinical Trial.Drug design, development and therapy · 2025Trial
- Liposomal Bupivacaine Incisional Infiltration for Postoperative Analgesia After Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy: A Randomized Placebo-Controlled Trial.Pain and therapy · 2026Article
- Application of bupivacaine liposomes for iliac fascia blockade in total hip arthroplasty.Journal of orthopaedic surgery and research · 2026Review
- Optimizing liposomal bupivacaine in thoracoscopic enhanced recovery: precision stratification, protocol standardization, and equitable access: A Letter to the Editor about "Effect of liposomal bupivacaine for preoperative erector spinae plane block on postoperative pain following video-assisted thoracoscopic lung resection: a multicenter, randomized, double-blind, clinical trial".International journal of surgery (London, England) · 2026Article
- Case Report: Dynamic characteristics of myocardial depression after severe bupivacaine-induced local anesthetic systemic toxicity.Frontiers in cardiovascular medicine · 2026Article
- Liposomal bupivacaine in lower extremity arthroplasty: a comprehensive review.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Hydrogel Drug Delivery Systems and Liposomal Bupivacaine: Innovations and Future Perspectives in Pain Management.Journal of clinical medicine · 2025Review
- Intrapleural injection of bupivacaine liposome for pain management after thoracoscopic surgery.Scientific reports · 2025Article
- Pharmacokinetics and efficacy of a novel long-acting bupivacaine formulation for cornual nerve block in calves.Frontiers in veterinary science · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLiposomal bupivacaine (LB) is a long-acting formulation of bupivacaine. The safety and efficacy of LB has been demonstrated across surgical procedures. However, pharmacokinetic (PK) parameters and safety of LB in the Chinese population have not been assessed.
methodsIn this single-arm, single center, phase 1, open-label study, PK and safety of local infiltration with LB 266 mg were assessed in healthy Chinese adults. Eligible participants were aged 18 to 55 years with biologic parents and grandparents of Chinese ethnicity, in generally good health (i.e., no clinically significant abnormalities), and with a body mass index (BMI) 19.0 to 24.0 kg/m
resultsParticipants (N = 20) were predominantly men (80 %); mean age was 32 years; and mean BMI was 21.8 kg/m
conclusionsAfter single-dose administration of LB, PK measures were similar to a previously reported profile in US adults. The highest observed peak plasma concentration of bupivacaine was several-fold below the plasma concentration threshold accepted as being associated with neurotoxicity or cardiotoxicity (2000-4000 ng/mL). These data support that LB is well tolerated and safe in individuals of Chinese descent.
trial registrationNCT04158102 (ClinicalTrials.gov identifier), Date of registration: November 5, 2019.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.