Evidence map›Paper›PMID 34315409›Full record

ArticleBMC genomics2021

Dynamic changes of miRNAs in skeletal muscle development at New Zealand rabbits.

Jing Jing, Xichun Jiang, Cuiyun Zhu, Qi Zheng, Qianyun Ji, Huiqun Yin, Jingtong Huang, Yixiao Zhu, Jiao Wang, Shuaiqi Qin and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Role of Non-Coding RNAs in Pathogenesis, Diagnosis, and Therapy of Legg-Calvé-Perthes Disease: A Systematic Review.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jing Jing *College of Animal Science and Technology, Anhui Agricultural University, Anhui, 230036, Hefei, People's Republic of China.
Xichun Jiang *Institute of Animal Science and Veterinary Medicine, Anhui Academy of Agricultural Sciences, Anhui, 230031, Hefei, People's Republic of China.
Cuiyun Zhu *College of Animal Science and Technology, Anhui Agricultural University, Anhui, 230036, Hefei, People's Republic of China.
Qi ZhengCollege of Animal Science and Technology, Anhui Agricultural University, Anhui, 230036, Hefei, People's Republic of China.
Qianyun JiCollege of Animal Science and Technology, Anhui Agricultural University, Anhui, 230036, Hefei, People's Republic of China.
Huiqun YinReproductive Medicine Center, The 901st Hospital, Anhui, 230031, Hefei, People's Republic of China.
Jingtong HuangCollege of Animal Science and Technology, Anhui Agricultural University, Anhui, 230036, Hefei, People's Republic of China.
Yixiao ZhuCollege of Animal Science and Technology, Anhui Agricultural University, Anhui, 230036, Hefei, People's Republic of China.
Jiao WangCollege of Animal Science and Technology, Anhui Agricultural University, Anhui, 230036, Hefei, People's Republic of China.
Shuaiqi QinCollege of Animal Science and Technology, Anhui Agricultural University, Anhui, 230036, Hefei, People's Republic of China.
Yinghui LingCollege of Animal Science and Technology, Anhui Agricultural University, Anhui, 230036, Hefei, People's Republic of China. lingyinghui@ahau.edu.cn.
Anhui Agricultural University · CNAnhui Academy of Agricultural Sciences · CN

Funding

Anhui Province Academic and Technology Leader Reserve Talent Project 2019H206Anhui Province Cattle and Sheep Competitiveness Improvement Action Plan AHCYJSTX-07-202107National Natural Science Foundation of China 31772566
6 · The paper itself

Abstract

backgroundmiRNA is one of the crucial roles in the complex and dynamic network that regulates the development of skeletal muscle. The landscape of skeletal muscle miRNAs from fetus to adult in New Zealand rabbits has not been revealed yet.

resultsIn this study, nine RNA-seq libraries of fetus, child and adult rabbits' leg muscles were constructed. A total of 278 differentially expressed miRNAs (DEmiRNAs) were identified. In the fetus vs. child group, the main functional enrichments were involved in membrane and transport. Pathway enriched terms of up-regulated DEmiRNAs were connected with the differentiation and hypertrophy of skeletal muscle, and down-regulated ones were related to muscle structure and metabolic capacity. In the child vs. adult group, functions were associated to positioning and transportation, and pathways were relevant to ECM, muscle structure and hypertrophy. Finally, ocu-miR-185-3p and ocu-miR-370-3p, which had the most target genes, were identified as hub-miRNAs in these two groups.

conclusionsIn short, we summarized the highly expressed and uniquely expressed DEmiRNAs of fetus, child and adult rabbits' leg muscles. Besides, the potential functional changes of miRNAs in two consecutive stages have been explored. Among them, the ocu-miR-185-3p and ocu-miR-370-3p with the most target genes were selected as hub-miRNAs. These data improved the understanding of the regulatory molecules of meat rabbit development, and provided a novel perspective for molecular breeding of meat rabbits.

Indexed as

MicroRNAsAnimalsGene Expression ProfilingMuscle DevelopmentMuscle, SkeletalRabbitsRNA-SeqMicroRNAsDevelopmentmiRNARabbitSkeletal musclesRNA-seq

Identifiers

PMID34315409
PMCPMC8314457
OpenAlexW3162001433

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.