ArticleRenal failure2021
Predictors of coronary artery calcification and its association with cardiovascular events in patients with chronic kidney disease.
Article in Renal failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 36 citations in OpenAlex.
- Development of a Preoperative Transthoracic Echocardiography-Based Nomogram for Predicting 1-Year Cardiovascular Events in End-Stage Renal Disease Kidney Transplant Recipients.Echocardiography (Mount Kisco, N.Y.) · 2026Article
- Development and validation of a nomogram for predicting abdominal aortic calcification in maintenance hemodialysis patients.International urology and nephrology · 2026Article
- Article
- Correlation between complement C3 level and abdominal aortic calcification in non-dialysis chronic kidney disease patients: a cross-sectional study.Frontiers in medicine · 2026Article
- Biomarkers for Personalised Primary or Secondary Prevention in Cardiovascular Diseases: A Rapid Scoping Review.International journal of molecular sciences · 2025Article
- The Association of Adropin with Asymptomatic Coronary Calcification in Patients in Early Stages of Chronic Kidney Disease.International journal of molecular sciences · 2025Article
- Association between blood pressure in the first-year post-kidney transplantation and pre-transplant coronary calcium scoring: a retrospective cohort study.Annals of medicine and surgery (2012) · 2025Article
- Cardiovascular disease risk assessment, exercise training, and management of complications in patients with chronic kidney disease.International journal of cardiology. Cardiovascular risk and prevention · 2025Review
- Serum midkine level and its association with subclinical coronary artery calcification and carotid atherosclerosis in chronic kidney disease.BMC nephrology · 2025Article
- Predictive nomogram model for severe coronary artery calcification in end-stage kidney disease patients.Renal failure · 2024Article
- The Serum NLRP1 Level and Coronary Artery Calcification: From Association to Development of a Risk-Prediction Nomogram.Reviews in cardiovascular medicine · 2024Article
- The Relationship of Fetuin-A with Coronary Calcification, Carotid Atherosclerosis, and Mortality Risk in Non-Dialysis Chronic Kidney Disease.Journal of lipid and atherosclerosis · 2024Article
- High Copper Intake Is Associated with Decreased Likelihood of Abdominal Aortic Calcification in Middle-Aged and Older US Adults.Biological trace element research · 2024Article
- Circulating miR-129-3p in combination with clinical factors predicts vascular calcification in hemodialysis patients.Clinical kidney journal · 2024Article
- GPCRs overexpression and impaired fMLP-induced functions in neutrophils from chronic kidney disease patients.Frontiers in immunology · 2024Article
- Phosphate and Coronary Artery Disease in Patients with Chronic Kidney Disease.Journal of atherosclerosis and thrombosis · 2024Review
- Article
- Neutrophil and lymphocyte count as predictors of the location of calcific coronary lesions in patients treated with rotational atherectomy.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2023Article
- Regulatory effects of nutritional and metabolic disorders on vascular calcification in chronic kidney disease: a narrative review.Annals of translational medicine · 2023Review
- Inflammatory Determinants and Associated Morbidity in Hemodialysis Patients.Journal of personalized medicine · 2023Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the predictors of coronary artery calcification (CAC) and its association with cardiovascular events (CVE) in patients with stage 3-5 chronic kidney disease (CKD).
methodTwo hundred ninety CKD patients in our nephrology department were enrolled from 2018 to May 2019. The levels of matrix Gla protein (MGP) and interleukin 6 (IL-6) were measured
resultsThe prevalence of CAC was up to 57.93%. We found that age, diabetes mellitus, hyperphosphatemia, dialysis duration, and the neutrophil-lymphocyte ratio (NLR) were positively associated with CAC in all patients. In 131 patients, we demonstrated that higher IL-6 and lower MGP levels were associated with CAC. A Cox proportional hazard model demonstrated that moderate to severe CAC was correlated with an increased risk for CVE [Hazard Ratio (HR): 7.250; 95% confidence interval (CI): 3.192-16.470], and a higher MGP level was associated with a reduced risk for CVE (HR: 0.340; 95% CI: 0.124-0.933).
conclusionsThe prevalence of CAC in patients with CKD is a significant issue. Older age, hyperphosphatemia, dialysis duration, diabetes mellitus, IL-6, and the NLR are associated with CAC. In addition, higher MGP levels represent protective factor for CAC. Moderate to severe CAC, and lower MGP levels are associated with an increased risk for CVE.
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