Evidence map›Paper›PMID 34315032›Full record

ArticleComputers in biology and medicine2021

The effect of interpolating low amplitude leads on the inverse reconstruction of cardiac electrical activity.

Ali S Rababah, Laura R Bear, Yesim Serinagaoglu Dogrusoz, Wilson Good, Jake Bergquist, Job Stoks, Rob MacLeod, Khaled Rjoob, Michael Jennings, James Mclaughlin and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Computers in biology and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 5 countries.

Ali S RababahSchool of Engineering, Ulster University, Northern Ireland, UK. Electronic address: Rababah-a@ulster.ac.uk.
Laura R BearIHU LIRYC, Université de Bordeaux, CRCTB Inserm U1045, Bordeaux, France.
Yesim Serinagaoglu DogrusozElectrical-Electronics Engineering Department, Middle East Technical University, Ankara, Turkey.
Wilson GoodScientific Computing and Imaging Institute, University of Utah, SLC, UT, USA.
Jake BergquistScientific Computing and Imaging Institute, University of Utah, SLC, UT, USA.
Job StoksDepartment of Cardiology, Maastricht University, Maastricht, the Netherlands.
Rob MacLeodScientific Computing and Imaging Institute, University of Utah, SLC, UT, USA.
Khaled RjoobSchool of Engineering, Ulster University, Northern Ireland, UK.
Michael JenningsSchool of Engineering, Ulster University, Northern Ireland, UK.
James MclaughlinSchool of Engineering, Ulster University, Northern Ireland, UK.
Dewar D FinlaySchool of Engineering, Ulster University, Northern Ireland, UK.
University of Ulster · GBUniversity of Utah · USMaastricht University · NLMiddle East Technical University · TRUniversité de Bordeaux · FR

Funding

TRD - VisualizationP41GM103545 · NIGMS · UNIVERSITY OF UTAH · PI JOHNSON, CHRISTOPHER R., MACLEOD, ROB S. · 2012 to 2019
$9.7M
Integration of Uncertainty Quantification with SCIRun Bioelectric Field Simulation PipelineU24EB029012 · NIBIB · UNIVERSITY OF UTAH · PI MACLEOD, ROB S. · 2019 to 2021
$1.1M
NIBIB NIH HHS U24 EB029012NIGMS NIH HHS P41 GM103545
6 · The paper itself

Abstract

Electrocardiographic imaging is an imaging modality that has been introduced recently to help in visualizing the electrical activity of the heart and consequently guide the ablation therapy for ventricular arrhythmias. One of the main challenges of this modality is that the electrocardiographic signals recorded at the torso surface are contaminated with noise from different sources. Low amplitude leads are more affected by noise due to their low peak-to-peak amplitude. In this paper, we have studied 6 datasets from two torso tank experiments (Bordeaux and Utah experiments) to investigate the impact of removing or interpolating these low amplitude leads on the inverse reconstruction of cardiac electrical activity. Body surface potential maps used were calculated by using the full set of recorded leads, removing 1, 6, 11, 16, or 21 low amplitude leads, or interpolating 1, 6, 11, 16, or 21 low amplitude leads using one of the three interpolation methods - Laplacian interpolation, hybrid interpolation, or the inverse-forward interpolation. The epicardial potential maps and activation time maps were computed from these body surface potential maps and compared with those recorded directly from the heart surface in the torso tank experiments. There was no significant change in the potential maps and activation time maps after the removal of up to 11 low amplitude leads. Laplacian interpolation and hybrid interpolation improved the inverse reconstruction in some datasets and worsened it in the rest. The inverse forward interpolation of low amplitude leads improved it in two out of 6 datasets and at least remained the same in the other datasets. It was noticed that after doing the inverse-forward interpolation, the selected lambda value was closer to the optimum lambda value that gives the inverse solution best correlated with the recorded one.

Indexed as

Activation times mapsHybrid interpolationInverse-forward interpolationInverse reconstruction of cardiac electrical activityLaplacian interpolationLow amplitude leadsPotential maps

Identifiers

PMID34315032
PMCPMC8461453
OpenAlexW3184990521

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.