Evidence map›Paper›PMID 34314863›Full record

ArticlePhotodiagnosis and photodynamic therapy2021

Ultraviolet-A light reduces cellular cytokine release from human endotracheal cells infected with Coronavirus.

Gabriela Leite, Mark Pimentel, Ruchi Mathur, Gillian M Barlow, Yin Chan, Gil Y Melmed, Ali Rezaie

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Photodiagnosis and photodynamic therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gabriela LeiteMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Mark PimentelMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA; Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai, Los Angeles, CA, USA.
Ruchi MathurMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai, Los Angeles, CA, USA.
Gillian M BarlowMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Yin ChanKarsh Division of Gastroenterology and Hepatology, Cedars-Sinai, Los Angeles, CA, USA.
Gil Y MelmedKarsh Division of Gastroenterology and Hepatology, Cedars-Sinai, Los Angeles, CA, USA.
Ali RezaieMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA; Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai, Los Angeles, CA, USA. Electronic address: ali.rezaie@cshs.org.
Cedars-Sinai Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAn important clinical feature of coronavirus disease 2019 (COVID-19) is hypercytokinemia (cytokine storm). We previously showed that narrow band ultraviolet-A (NB-UVA) treatment salvages coronavirus (CoV)-229E-infected human tracheal cells, and that daily endotracheal NB-UVA therapy reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) levels in human subjects, with improved clinical outcomes. Here, we examined NB-UVA effects on cytokine release during CoV-229E infection.

methodsPrimary human tracheal epithelial cells were transfected with CoV-229E, then exposed to 2 mW/cm

resultsPro-inflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF), and chemokines IL-8, monocyte chemoattractant protein-1 (MCP1), and interferon gamma-induced protein 10 (IP-10), were significantly increased in CoV-229E-infected cells, and significantly decreased following NB-UVA treatment. Interferon (IFN)-α2, IFN-γ, and IL-10 were not upregulated in response to CoV-229E. Metabolic pathway predictions indicated hypercytokinemia as the top inflammatory response in CoV-229E-infected cells, whereas the top predicted pathway in CoV-229E-infected/UVA-exposed cells was the recovery stage of severe acute respiratory syndrome.

conclusionsHuman tracheal epithelial cells infected with CoV-229E showed reduced cytokine secretions including IL-6, TNF, IL-8, and MCP-1, following NB-UVA exposure. This reduction of cytokine levels in vitro, coupled with previously identified reduced cell death in CoV-229E-infected/UVA-exposed cells, suggests that determining UVA effects on cytokine storm in human SARS-Co-V2 patients is warranted.

Indexed as

COVID-19PhotochemotherapyCytokinesHumansPhotosensitizing AgentsSARS-CoV-2CytokinesPhotosensitizing AgentsCoronavirus-229ECOVID-19Cytokine stormHuman tracheal epithelial cellsInterleukin-6Tumor necrosis factorUltraviolet light-AUV-A

Identifiers

PMID34314863
PMCPMC8310417
OpenAlexW3184555216

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.