ArticleNeuroImage2021
Frequency drift in MR spectroscopy at 3T.
Open access · goldAbstract read
In one paragraph
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
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- Correcting motion-related BScientific reports · 2026Article
- Assessing the reliability of hippocampal single-voxel proton magnetic resonance spectroscopy through intra-class effect decomposition.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Unconscious switching of dorsal and medial pathways for plasticity and stability during NREM and REM sleep.bioRxiv : the preprint server for biology · 2025Article
- Real-time radiation beam imaging on an MR linear accelerator using quantitative TMedical physics · 2025Article
- Test-retest precision of brain metabolites in healthy participants usingQuantitative imaging in medicine and surgery · 2025Article
- Simultaneous frequency and phase corrections of single-shot MRS data using cross-correlation.Magnetic resonance in medicine · 2025Article
- Quantifying brain development in the HEALthy Brain and Child Development (HBCD) Study: The magnetic resonance imaging and spectroscopy protocol.Developmental cognitive neuroscience · 2024Article
- Model-based frequency-and-phase correction ofMagnetic resonance in medicine · 2024Article
- Accelerated 3D metabolite TMagnetic resonance in medicine · 2024Article
- Integrated Short-TE and Hadamard-edited Multi-Sequence (ISTHMUS) for advanced MRS.Journal of neuroscience methods · 2024Article
- Simultaneous multi-transient linear-combination modeling of MRS data improves uncertainty estimation.Magnetic resonance in medicine · 2024Article
- Universal dynamic fitting of magnetic resonance spectroscopy.Magnetic resonance in medicine · 2024Article
- Integrated Short-TE and Hadamard-edited Multi-Sequence (ISTHMUS) for Advanced MRS.bioRxiv : the preprint server for biology · 2024Article
- Impact of acquisition and modeling parameters on the test-retest reproducibility of edited GABA.NMR in biomedicine · 2024Article
- Simultaneous multi-transient linear-combination modeling of MRS data improves uncertainty estimation.bioRxiv : the preprint server for biology · 2024Article
- Real-Time Semi-Automated and Automated Voxel Placement using fMRI Targets for Repeated Acquisition Magnetic Resonance Spectroscopy.Journal of neuroscience methods · 2023Article
- Model-informed unsupervised deep learning approaches to frequency and phase correction of MRS signals.Magnetic resonance in medicine · 2023Article
- On the relationship between GABA+ and glutamate across the brain.NeuroImage · 2022Article
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Authors and funding
135 authors at 20 institutions in 19 countries.
Steve C N HuiRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Mark MikkelsenRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Helge J ZöllnerRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Vishwadeep AhluwaliaGSU/GT Center for Advanced Brain Imaging, Georgia Institute of Technology, Atlanta, GA USA.
Sarael AlcauterInstituto de Neurobiología, Universidad Nacional Autónoma de México, Queretaro, Mexico.
Laima BaltusisCenter for Cognitive and Neurobiological Imaging, Stanford University, Stanford, CA USA.
Deborah A BaranyDepartment of Kinesiology, University of Georgia, and Augusta University/University of Georgia Medical Partnership, Athens, GA USA.
Laura R BarlowDepartment of Radiology, Faculty of Medicine, The University of British Columbia, Vancouver, Canada.
Robert BeckerCenter for Innovative Psychiatry and Psychotherapy Research, Department Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Jeffrey I BermanDepartment of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA USA.
Adam BerringtonSir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK.
Pallab K BhattacharyyaImaging Institute, The Cleveland Clinic, Cleveland, OH USA.
Jakob Udby BlicherCenter of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark.
Wolfgang BognerDepartment of Biomedical Imaging and Image-guided Therapy, High-Field MR Center, Medical University of Vienna, Vienna, Austria.
Mark S BrownDepartment of Radiology, Medical Physics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Vince D CalhounTri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, GA USA.
Ryan CastilloNeuRA Imaging, Neuroscience Research Australia, Randwick, Australia.
Kim M CecilDepartment of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH USA.
Yeo Bi ChoiDepartment of Psychological and Brain Sciences, Dartmouth College, Hanover, NH USA.
Winnie C W ChuDepartment of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, China.
William T ClarkeWellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Alexander R CravenDepartment of Biological and Medical Psychology, University of Bergen, Haukeland University Hospital, Bergen, Norway.
Koen CuypersREVAL Rehabilitation Research Institute (REVAL), Hasselt University, Diepenbeek, Belgium; Department of Movement Sciences, KU Leuven, Leuven, Belgium.
Michael DackoDepartment of Radiology, Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Camilo de la Fuente-SandovalLaboratory of Experimental Psychiatry & Neuropsychiatry Department, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.
Patricia DesmondDepartment of Radiology, University of Melbourne/ Royal Melbourne Hospital, Melbourne, Australia.
Aleksandra DomagalikBrain Imaging Core Facility, Malopolska Centre of Biotechnology, Jagiellonian University, Kraków, Poland.
Julien DumontUniv. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US 41 - UMS 2014 - PLBS, F-59000 Lille, France.
Niall W DuncanGraduate Institute of Mind, Brain and Consciousness, Taipei Medical University, Taipei, Taiwan.
Ulrike DydakSchool of Health Sciences, Purdue University, West Lafayette, IN USA.
Katherine DykeSchool of Psychology, University of Nottingham, Nottingham, UK.
David A EdmondsonDepartment of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH USA.
Gabriele EndeCenter for Innovative Psychiatry and Psychotherapy Research, Department Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Lars ErslandDepartment of Clinical Engineering, University of Bergen, Haukeland University Hospital, Bergen, Norway.
C John EvansCUBRIC, Cardiff university, Cardiff, Wales, UK.
Alan S R FerminCenter for Brain, Mind and KANSEI Sciences Research, Hiroshima University, Hiroshima, Japan.
Antonio FerrettiDepartment of Neuroscience, Imaging and Clinical Sciences, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy.
Ariane FillmerPhysikalisch-Technische Bundesanstalt (PTB), Braunschweig und Berlin, Germany.
Tao GongDepartment of Imaging and Nuclear Medicine, Shandong Medical Imaging Research Institute, Shandong University, Jinan, China.
Ian GreenhouseDepartment of Human Physiology, University of Oregon, Eugene, OR USA.
James T GristDepartment of Physiology, Anatomy, and Genetics, Oxford Centre for Magnetic Resonance / Department of Radiology, The Churchill Hospital, The University of Oxford, Oxford, UK.
Meng GuDepartment of Radiology, Stanford University, Stanford, CA, USA.
Ashley D HarrisDepartment of Radiology, University of Calgary, Calgary, Canada.
Katarzyna HatConsciousness Lab, Institute of Psychology, Jagiellonian University, Kraków, Poland.
Stefanie HebaDepartment of Neurology, BG University Hospital Bergmannsheil, Bochum, Germany.
Eva HeckovaDepartment of Biomedical Imaging and Image-guided Therapy, High-Field MR Center, Medical University of Vienna, Vienna, Austria.
John P HegartyDepartment of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, USA.
Kirstin-Friederike HeiseDepartment of Movement Sciences, KU Leuven, Leuven, Belgium.
Shiori HondaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Aaron JacobsonDepartment of Radiology / Psychiatry, University of California San Diego, San Diego, CA USA.
Jacobus F A JansenDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.
Christopher W JenkinsCUBRIC, Cardiff university, Cardiff, Wales, UK.
Stephen J JohnstonPsychology Department / Clinical Imaging Facility, Swansea University, Swansea, UK.
Christoph JuchemDepartments of Biomedical Engineering and Radiology, Columbia University, New York, NY USA.
Alayar KangarluDepartment of Psychiatry, Columbia University Irving Medical Center/New York State Psychiatric Institute, New York, NY USA.
Adam B KerrCenter for Cognitive and Neurobiological Imaging, Stanford University, Stanford, CA USA.
Karl LandheerDepartments of Biomedical Engineering and Radiology, Columbia University, New York, NY USA.
Thomas LangeDepartment of Radiology, Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Phil LeeDepartment of Radiology / Hoglund Biomedical Imaging Center, University of Kansas Medical Center, Kansas City, KS USA.
Swati Rane LevendovszkyDepartment of Radiology, University of Washington, Seattle, WA USA.
Catherine LimperopoulosDeveloping Brain Institute, Diagnostic Imaging and Radiology, Children's National Hospital, Washington, DC USA.
Feng LiuDepartment of Psychiatry, Columbia University Irving Medical Center/New York State Psychiatric Institute, New York, NY USA.
William LloydDivision of Informatics, Imaging & Data Sciences, University of Manchester, Manchester, UK.
David J LythgoeDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Maro G MachizawaCenter for Brain, Mind and KANSEI Sciences Research, Hiroshima University, Hiroshima, Japan.
Erin L MacMillanDepartment of Radiology, Faculty of Medicine, The University of British Columbia, Vancouver, Canada; Philips Canada, Markham, ON, Canada.
Richard J MaddockDepartment of Psychiatry and Behavioral Sciences, University of California Davis, Imaging Research Center, Davis, CA USA.
Andrei V ManzhurtsevDepartment of Radiology, Clinical and Research Institute of Emergency Pediatric Surgery and Trauma, Moscow, Russia; Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Moscow, Russia.
María L Martinez-GudinoDepartamento de Imágenes Cerebrales, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, Mexico.
Jack J MillerDepartment of Physics, University of Oxford, Oxford, UK; The MR Research Centre & The PET Research Centre, Aarhus University, Aarhus, DK.
Heline MirzakhanianDepartment of Radiology / Psychiatry, University of California San Diego, San Diego, CA USA.
Marta Moreno-OrtegaDepartment of Psychiatry, Columbia University Irving Medical Center/New York State Psychiatric Institute, New York, NY USA.
Paul G MullinsBangor Imaging Unit, Department of Psychology, Bangor University, Bangor, Wales, UK.
Shinichiro NakajimaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Jamie NearDouglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, Canada.
Ralph NoeskeGE Healthcare, Berlin, Germany.
Wibeke NordhøyNORMENT, Division of Mental Health and Addiction and Department of Diagnostic Physics, Division of Radiology and Nuclear Medicine, Oslo University Hospital / Department of Psychology, University of Oslo, Oslo, Norway.
Georg OeltzschnerRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Raul Osorio-DuranDepartamento de Imágenes Cerebrales, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, Mexico.
Maria C G OtaduyLIM44, Instituto e Departamento de Radiologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Erick H PasayeInstituto de Neurobiología, Universidad Nacional Autónoma de México, Queretaro, Mexico.
Ronald PeetersDepartment of Imaging & Pathology, Department of Radiology, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
Scott J PeltierFunctional MRI Laboratory, University of Michigan, Ann Arbor, MI USA.
Ulrich PilatusInstitute of Neuroradiology, Goethe-University Frankfurt, Frankfurt, Germany.
Nenad PolomacInstitute of Neuroradiology, Goethe-University Frankfurt, Frankfurt, Germany.
Eric C PorgesCenter for Cognitive Aging and Memory, McKnight Brain Institute, Department of Clinical and Health Psychology, College of Public Health and Health Professions. Department of Neuroscience, College of Medicine, University of Florida, Gainesville, USA.
Subechhya PradhanDeveloping Brain Institute, Diagnostic Imaging and Radiology, Children's National Hospital, Washington, DC USA.
James Joseph PrisciandaroDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC USA.
Nicolaas A PutsDepartment of Forensic & Neurodevelopmental Sciences, Sackler Institute for Translational Neurodevelopment, King's College London, London, UK.
Caroline D RaeNeuRA Imaging, Neuroscience Research Australia, Randwick, Australia.
Francisco Reyes-MadrigalLaboratory of Experimental Psychiatry & Neuropsychiatry Department, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.
Timothy P L RobertsDepartment of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA USA.
Caroline E RobertsonDepartment of Psychological and Brain Sciences, Dartmouth College, Hanover, NH USA.
Jens T RosenbergMcKnight Brain Institute, AMRIS, University of Florida, Gainesville, FL USA.
Diana-Georgiana RotaruDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Ruth L O'Gorman TuuraCenter for MR Research, University Children's Hospital, Zurich, University of Zurich, Switzerland.
Muhammad G SalehDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, USA.
Kristian SandbergCenter of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark.
Ryan SangillCenter of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark.
Keith SchembriMedical Physics, Mater Dei Hospital, Imsida, Malta.
Anouk SchranteeDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Natalia A SemenovaDepartment of Radiology, Clinical and Research Institute of Emergency Pediatric Surgery and Trauma, Moscow, Russia; Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Moscow, Russia.
Debra SingelDepartment of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Rouslan SitnikovClinical Neuroscience, MRI Centre, Karolinska Institute, Stockholm, Sweden.
Jolinda SmithLewis Center for Neuroimaging, University of Oregon, Eugene, OR USA.
Yulu SongDepartment of Imaging and Nuclear Medicine, Shandong Medical Imaging Research Institute, Shandong University, Jinan, China.
Craig StarkDepartment of Neurobiology and Behavior, Facility for Imaging and Brain Research (FIBRE) & Campus Center for Neuroimaging (CCNI), School of Biological Sciences, University of California, Irvine, Irvine, CA USA.
Diederick StoffersSpinoza Centre for Neuroimaging, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.
Stephan P SwinnenDepartment of Movement Sciences, KU Leuven, Leuven, Belgium.
Rongwen TainDepartment of Neurobiology and Behavior, Facility for Imaging and Brain Research (FIBRE) & Campus Center for Neuroimaging (CCNI), School of Biological Sciences, University of California, Irvine, Irvine, CA USA.
Costin TanaseDepartment of Psychiatry and Behavioral Sciences, University of California Davis, Imaging Research Center, Davis, CA USA.
Sofie TapperRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Martin TegenthoffDepartment of Neurology, BG University Hospital Bergmannsheil, Bochum, Germany.
Thomas ThielInstitute of Clinical Neuroscience and Medical Psychology, University Dusseldorf, Medical Faculty, Düsseldorf, Germany.
Marc ThiouxDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Peter TruongBrain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada.
Pim van DijkDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Nolan VellaMedical Physics, Mater Dei Hospital, Imsida, Malta.
Rishma VidyasagarMelbourne Dementia Research Centre, Florey Institute of Neurosciences and Mental Health, Melbourne, Australia.
Andrej VovkFaculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Guangbin WangDepartment of Imaging and Nuclear Medicine, Shandong Medical Imaging Research Institute, Shandong University, Jinan, China.
Lars T WestlyeNORMENT, Division of Mental Health and Addiction and Department of Diagnostic Physics, Division of Radiology and Nuclear Medicine, Oslo University Hospital / Department of Psychology, University of Oslo, Oslo, Norway.
Timothy K WilburDepartment of Radiology, University of Washington, Seattle, WA USA.
William R WilloughbyDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL USA.
Martin WilsonCentre for Human Brain Health and School of Psychology, University of Birmingham, Birmingham, UK.
Hans-Jörg WittsackDepartment of Diagnostic and Interventional Radiology, University Düsseldorf, Medical Faculty, Düsseldorf, Germany.
Adam J WoodsCenter for Cognitive Aging and Memory, McKnight Brain Institute, Department of Clinical and Health Psychology, College of Public Health and Health Professions. Department of Neuroscience, College of Medicine, University of Florida, Gainesville, USA.
Yen-Chien WuDepartment of Radiology, TMU-Shuang Ho Hospital, New Taipei City, Taiwan.
Junqian XuDepartment of Radiology and Psychiatry, Baylor College of Medicine, Houston, USA.
Maria Yanez LopezPerinatal Imaging & Health, King's College London, London, UK.
David K W YeungDepartment of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, China.
Qun ZhaoBioimaging Research Center, Department of Physics and Astronomy, University of Georgia, Athens, GA USA.
Xiaopeng ZhouSchool of Health Sciences, Purdue University, West Lafayette, IN USA.
Gasper ZupanFaculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Richard A E EddenRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA. Electronic address: raee2@jhu.edu.
Johns Hopkins University · USJohns Hopkins Medicine · USPurdue University West Lafayette · USKing's College London · GBHeinrich Heine University Düsseldorf · DEUniversity of Nottingham · GBKennedy Krieger Institute · USStanford University · USDartmouth College · USHiroshima University · JPShandong University · CNUniversidad Nacional Autónoma de México · MXAarhus University · DKCardiff University · GBChinese University of Hong Kong · HKCincinnati Children's Hospital Medical Center · USGeorgia Institute of Technology · USGoethe University Frankfurt · DEKeio University · JPKU Leuven · BE
Funding
The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Crystal M. Glover · 2020 to 2026
$27.9MTR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2012 to 2020
$13.1MTRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9MThe Intellectual and Developmental Disabilities Research Center (IDDRC) at CHOP/PennP50HD105354 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI Michael Byrne Robinson · 2021 to 2026
$9.2MUniversal GABA-edited MRS at 3TR01EB016089 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Richard Anthony Edward Edden · 2013 to 2026
$5.4MSimultaneous Hadamard Editing of GABA and GlutathioneR01EB023963 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI EDDEN, RICHARD ANTHONY EDWARD · 2017 to 2024
$3.8MBiomarkers of Conversion Risk and Treatment Response in Early-Stage SchizophreniaR01MH110270 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI GIRGIS, RAGY RAMSIS, KEGELES, LAWRENCE S · 2017 to 2021
$3.7MElectrophysiological Signatures of Language Impairment in Autism Spectrum DisordeR01DC008871 · NIDCD · CHILDREN'S HOSP OF PHILADELPHIA · PI ROBERTS, TIMOTHY P · 2007 to 2018
$3.6MGabapentin for Restoring GABA/glutamate Homeostasis in Co-occurring Bipolar and Cannabis Use Disorders: A Randomized, Double-blind, Placebo-controlled, Parallel-group, Clinical MRI StudyR01DA054275 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PRISCIANDARO, JAMES JOSEPH · 2021 to 2025
$3.1MImaging Framework for Testing GABAergic/glutamatergic Drugs in Bipolar AlcoholicsR01AA025365 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PRISCIANDARO, JAMES JOSEPH · 2017 to 2022
$2.7MAdvanced 3T for Structural and Functional Imaging at University of FloridaS10OD021726 · OD · UNIVERSITY OF FLORIDA · PI LONG, JOANNA R · 2017 to 2017
$2.0M3T MRI Scanner dedicated to Life Sciences ResearchS10OD012336 · OD · PURDUE UNIVERSITY · PI DYDAK, ULRIKE · 2015 to 2015
$2.0MNIAAA NIH HHS K01 AA025306NIAAA NIH HHS R01 AA025365NIA NIH HHS K99 AG062230NIA NIH HHS P30 AG066519NIA NIH HHS R00 AG062230NIA NIH HHS R21 AG060245NIBIB NIH HHS K99 EB028828NIBIB NIH HHS P41 EB015909NIBIB NIH HHS P41 EB031771NIBIB NIH HHS R01 EB016089NIBIB NIH HHS R01 EB023963NICHD NIH HHS P50 HD105354NIDA NIH HHS K99 DA051315NIDA NIH HHS R01 DA054275NIDCD NIH HHS R01 DC008871NIH HHS S10 OD012336NIH HHS S10 OD021648NIH HHS S10 OD021726NIMH NIH HHS R01 MH110270
Abstract
purposeHeating of gradient coils and passive shim components is a common cause of instability in the B
methodA standardized protocol was developed for 80 participating sites using 99 3T MR scanners from 3 major vendors. Phantom water signals were acquired before and after an EPI sequence. The protocol consisted of: minimal preparatory imaging; a short pre-fMRI PRESS; a ten-minute fMRI acquisition; and a long post-fMRI PRESS acquisition. Both pre- and post-fMRI PRESS were non-water suppressed. Real-time frequency stabilization/adjustment was switched off when appropriate. Sixty scanners repeated the protocol for a second dataset. In addition, a three-hour post-fMRI MRS acquisition was performed at one site to observe change of gradient temperature and drift rate. Spectral analysis was performed using MATLAB. Frequency drift in pre-fMRI PRESS data were compared with the first 5:20 minutes and the full 30:00 minutes of data after fMRI. Median (interquartile range) drifts were measured and showed in violin plot. Paired t-tests were performed to compare frequency drift pre- and post-fMRI. A simulated in vivo spectrum was generated using FID-A to visualize the effect of the observed frequency drifts. The simulated spectrum was convolved with the frequency trace for the most extreme cases. Impacts of frequency drifts on NAA and GABA were also simulated as a function of linear drift. Data from the repeated protocol were compared with the corresponding first dataset using Pearson's and intraclass correlation coefficients (ICC).
resultsOf the data collected from 99 scanners, 4 were excluded due to various reasons. Thus, data from 95 scanners were ultimately analyzed. For the first 5:20 min (64 transients), median (interquartile range) drift was 0.44 (1.29) Hz before fMRI and 0.83 (1.29) Hz after. This increased to 3.15 (4.02) Hz for the full 30 min (360 transients) run. Average drift rates were 0.29 Hz/min before fMRI and 0.43 Hz/min after. Paired t-tests indicated that drift increased after fMRI, as expected (p < 0.05). Simulated spectra convolved with the frequency drift showed that the intensity of the NAA singlet was reduced by up to 26%, 44 % and 18% for GE, Philips and Siemens scanners after fMRI, respectively. ICCs indicated good agreement between datasets acquired on separate days. The single site long acquisition showed drift rate was reduced to 0.03 Hz/min approximately three hours after fMRI. DISCUSSION: This study analyzed frequency drift data from 95 3T MRI scanners. Median levels of drift were relatively low (5-min average under 1 Hz), but the most extreme cases suffered from higher levels of drift. The extent of drift varied across scanners which both linear and nonlinear drifts were observed.
Indexed as
Data AnalysisBrainDatabases, FactualHumansMagnetic Resonance ImagingMagnetic Resonance Spectroscopy3TFrequency driftMagnetic resonance spectroscopy (MRS)Multi-siteMulti-vendorPress
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