Evidence map›Paper›PMID 34314781›Full record

ArticleNeuropsychologia2021

Content-specific vulnerability of recent episodic memories in Alzheimer's disease.

Xenia Grande, David Berron, Anne Maass, Wilma A Bainbridge, Emrah Düzel

Open access · hybridAbstract read
In one paragraph

Article in Neuropsychologia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Tell me why: the missing w in episodic memory's what, where, and when.Cognitive, affective & behavioral neuroscience · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 4 countries.

Xenia GrandeGerman Center for Neurodegenerative Diseases, Magdeburg, Germany; Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University Magdeburg, Germany. Electronic address: xenia.grande@dzne.de.
David BerronGerman Center for Neurodegenerative Diseases, Magdeburg, Germany; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.
Anne MaassGerman Center for Neurodegenerative Diseases, Magdeburg, Germany.
Wilma A BainbridgeDepartment of Psychology, University of Chicago, Chicago, IL, USA.
Emrah DüzelGerman Center for Neurodegenerative Diseases, Magdeburg, Germany; Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University Magdeburg, Germany; Institute of Cognitive Neuroscience, University College London, United Kingdom. Electronic address: emrah.duezel@dzne.de.
German Center for Neurodegenerative Diseases · DELund University · SEUniversity of Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endel Tulving's episodic memory framework emphasizes the multifaceted re-experiencing of personal events. Indeed, decades of research focused on the experiential nature of episodic memories, usually treating recent episodic memory as a coherent experiential quality. However, recent insights into the functional architecture of the medial temporal lobe show that different types of mnemonic information are segregated into distinct neural pathways in brain circuits empirically associated with episodic memory. Moreover, recent memories do not fade as a whole under conditions of progressive neurodegeneration in these brain circuits, notably in Alzheimer's disease. Instead, certain memory content seem particularly vulnerable from the moment of their encoding while other content can remain memorable consistently across individuals and contexts. We propose that these observations are related to the content-specific functional architecture of the medial temporal lobe and consequently to a content-specific impairment of memory at different stages of the neurodegeneration. To develop Endel Tulving's inspirational legacy further and to advance our understanding of how memory function is affected by neurodegenerative conditions such as Alzheimer's disease, we postulate that it is compelling to focus on the representational content of recent episodic memories.

Indexed as

Alzheimer DiseaseCognitive DysfunctionMemory, EpisodicHumansMagnetic Resonance ImagingNeural PathwaysTemporal LobeAlzheimer's diseaseEpisodic memoryMedial temporal lobeMemorabilityMemory representations

Identifiers

PMID34314781
PMCPMC8434425
OpenAlexW3185036100

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.