ArticleCurrent biology : CB2021
The spatiotemporal organization of experience dictates hippocampal involvement in primary visual cortical plasticity.
Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Hippocampal mechanisms underlying the resolution of competition in memory and perception.Nature communications · 2026Article
- Impaired behavioral inhibition in Fmr1 KO mice is linked to disrupted visual cortex theta oscillations.Cell reports · 2026Article
- Experience-Dependent Plasticity to Visual Sequences in Mouse Anterior Cingulate Cortex Reflects Familiarity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Environmental Novelty Modulates Rapid Cortical Plasticity During Navigation.bioRxiv : the preprint server for biology · 2025Article
- Sleep and experience-dependent visual plasticity in the adult cerebral cortex: an update.Sleep · 2025Article
- The visual evoked potential is a sensitive and powerful measure of experience-dependent visual cortical plasticity in mice.Current opinion in neurobiology · 2025Review
- Oddball Evoked Deviant Responses Reflect Complex Context-Dependent Expectations in Mouse V1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Article
- Sleep is necessary for experience-dependent sequence plasticity in mouse primary visual cortex.Sleep · 2025Article
- Origin of visual experience-dependent theta oscillations.Current biology : CB · 2025Article
- M2 receptors are required for spatiotemporal sequence learning in mouse primary visual cortex.Journal of neurophysiology · 2024Article
- Dynamic predictive coding: A model of hierarchical sequence learning and prediction in the neocortex.PLoS computational biology · 2024Article
- Article
- Expectation violations produce error signals in mouse V1.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Successor-like representation guides the prediction of future events in human visual cortex and hippocampus.eLife · 2023Article
- Sex and estrous cycle affect experience-dependent plasticity in mouse primary visual cortex.PloS one · 2023Article
- Sensory Over-responsivity: A Feature of Childhood Psychiatric Illness Associated With Altered Functional Connectivity of Sensory Networks.Biological psychiatry · 2023Article
- Optogenetic manipulation of inhibitory interneurons can be used to validate a model of spatiotemporal sequence learning.Frontiers in computational neuroscience · 2023Article
- Hippocampal representations switch from errors to predictions during acquisition of predictive associations.Nature communications · 2022Article
Corrections and comments
- Commented on by
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The hippocampus and neocortex are theorized to be crucial partners in the formation of long-term memories. Here, we assess hippocampal involvement in two related forms of experience-dependent plasticity in the primary visual cortex (V1) of mice. Like control animals, those with hippocampal lesions exhibit potentiation of visually evoked potentials after passive daily exposure to a phase-reversing oriented grating stimulus, which is accompanied by long-term habituation of a reflexive behavioral response. Thus, low-level recognition memory is formed independently of the hippocampus. However, response potentiation resulting from daily exposure to a fixed sequence of four oriented gratings is severely impaired in mice with hippocampal damage. A feature of sequence plasticity in V1 of controls, which is absent in lesioned mice, is the generation of predictive responses to an anticipated stimulus element when it is withheld or delayed. Thus, the hippocampus is involved in encoding temporally structured experience, even within the primary sensory cortex.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.