Article in Molecular oral microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
5 authors at 1 institution in 1 country.
Rong MuDepartment of Restorative Dentistry, School of Dentistry, Oregon Health and Science University, Portland, Oregon, USA.
David AndersonDepartment of Restorative Dentistry, School of Dentistry, Oregon Health and Science University, Portland, Oregon, USA.
Justin MerrittDepartment of Restorative Dentistry, School of Dentistry, Oregon Health and Science University, Portland, Oregon, USA.
Hui WuDepartment of Integrative Biomedical & Diagnostic Sciences, School of Dentistry, Oregon Health and Science University, Portland, Oregon, USA.ORCID 0000-0003-2818-756X
Jens KrethDepartment of Restorative Dentistry, School of Dentistry, Oregon Health and Science University, Portland, Oregon, USA.ORCID 0000-0002-8599-8310
Oregon Health & Science University · US
Funding
Understanding the origins of rapid recurrence of pancreatic cancer after resectionP30CA069533 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Grace B Gill · 1997 to 2026
$60.5M
Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Kate E Keller · 1995 to 2026
$19.4M
Advancing studies of polymicrobial diseases via streptococcal geneticsR35DE028252 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI MERRITT, JUSTIN · 2018 to 2025
$7.8M
Glycosylation & Function of an Oral Streptococcal AdhesinR01DE017954 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WU, HUI · 2007 to 2022
$5.8M
SMALL MOLECULE INHIBITORS OF CARIOGENIC BIOFILMSR01DE022350 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Christian Corey Melander, Hui Wu · 2012 to 2026
$4.3M
Pyruvate oxidase: a molecular determinant of commensalism among the oral microbiomeR01DE029492 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI KRETH, JENS · 2020 to 2024
$2.5M
Pyruvate oxidase determines ecological fitness of oral streptococciR01DE021726 · NIDCR · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI KRETH, JENS · 2014 to 2018
$1.9M
BACTERIAL SECOND MESSENGER MEDIATED VIRULENCE REGULATION IN STREPTOCOCCUS MUTANSR01DE028329 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WU, HUI · 2019 to 2023
$1.7M
LTQ Orbitrap VelosS10OD012246 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI DAVID, LARRY L · 2012 to 2012
$854k
Pyruvate oxidase determines ecological fitness of oral streptococciR56DE021726 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI KRETH, JENS · 2018 to 2018
$545k
Streptococcal secretion of pyruvate - a novel antioxidant strategy in the oral biofilmR21DE029612 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI KRETH, JENS · 2020 to 2021
Streptococcal pyruvate oxidase (SpxB) is a hydrogen peroxide-generating enzyme and plays a critical role in Streptococcus sanguinis interspecies interactions, but less is known about its biochemistry. We examined SpxB subcellular localization using protein fractionation and microscopy and found SpxB to be primarily cytoplasmic, but a small portion is also membrane associated. Potential post-translational modifications of SpxB were determined using coimmunoprecipitation and mass spectrometry. Two mutant strains were constructed to further validate the presence of predicted site-specific post-translational modifications. These site mutated SpxB proteins exhibited reduced solubility in vivo, which likely contributes to the observed phenotypic changes in colony morphology, bacterial growth, and H
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Post-translational modification of Streptococcus sanguinis SpxB influences protein solubility and H · full record | OpenQuestion