ArticleBipolar disorders2022
Bipolar symptoms, somatic burden, and functioning in older-age bipolar disorder: Analyses from the Global Aging & Geriatric Experiments in Bipolar Disorder Database project.
Article in Bipolar disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- Bipolar Disorder in Older Adults: A Comprehensive Overview of Pharmacotherapy Patterns and Clinical Considerations.Drugs & aging · 2026Review
- Demographic and Clinical Correlates of Body Mass Index in Older Age Bipolar Disorder: Results from the GAGE-BD Project.Medicina (Kaunas, Lithuania) · 2026Article
- The spectrum of bipolar disorder in older adults.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- The role of predominant polarity in older age bipolar disorder.International journal of bipolar disorders · 2025Article
- Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD): Building a Global Consortium Benefiting People with Bipolar Disorder in Later Life.Current psychiatry reports · 2025Review
- Outpatient Management of Bipolar Disorder in Older Adults.Current psychiatry reports · 2025Review
- Factors associated with violence in bipolar disorder versus major depressive disorder: insights from a retrospective cross-sectional study of 141 aged patients with mood disorders.Frontiers in psychiatry · 2025Article
- The Changing Care of Older Adults With Bipolar Disorder: A Narrative Analysis.Qualitative health research · 2025Article
- Facing Life in Old Age: Exploring Resilience in Older Adults with Bipolar Disorder.Journal of clinical medicine · 2024Article
- Demographic and clinical associations to employment status in older-age bipolar disorder: Analysis from the GAGE-BD database project.Bipolar disorders · 2023Article
- Bipolar Disorder Among Older Adults: Newer Evidence to Guide Clinical Practice.Focus (American Psychiatric Publishing) · 2023Article
- Assessment and Management of Bipolar Disorder.Focus (American Psychiatric Publishing) · 2023Article
- Lithium use in childhood and adolescence, peripartum, and old age: an umbrella review.International journal of bipolar disorders · 2023Review
- Bipolar I and bipolar II subtypes in older age: Results from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE-BD) project.Bipolar disorders · 2023Article
- Study protocol - elucidating the neural correlates of functional remediation for older adults with bipolar disorder.Frontiers in psychiatry · 2023Article
- Demographic and clinical characteristics of lithium-treated older adults with bipolar disorder.Acta psychiatrica Scandinavica · 2022Article
- Symptom Severity Mixity in Older-Age Bipolar Disorder: Analyses From the Global Aging and Geriatric Experiments in Bipolar Disorder Database (GAGE-BD).The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022Article
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Authors and funding
21 authors at 16 institutions in 7 countries.
Funding
Abstract
objectiveLiterature on older-age bipolar disorder (OABD) is limited. This first-ever analysis of the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD) investigated associations among age, BD symptoms, comorbidity, and functioning.
methodsThis analysis used harmonized, baseline, cross-sectional data from 19 international studies (N = 1377). Standardized measures included the Young Mania Rating Scale (YMRS), Hamilton Depression Rating Scale (HAM-D), Montgomery-Asberg Depression Rating Scale (MADRS), and Global Assessment of Functioning (GAF).
resultsMean sample age was 60.8 years (standard deviation [SD] 12.2 years), 55% female, 72% BD I. Mood symptom severity was low: mean total YMRS score of 4.3 (SD 5.4) and moderate-to-severe depression in only 22%. Controlled for sample effects, both manic and depressive symptom severity appeared lower among older individuals (p's < 0.0001). The negative relationship between older age and symptom severity was similar across sexes, but was stronger among those with lower education levels. GAF was mildly impaired (mean =62.0, SD = 13.3) and somatic burden was high (mean =2.42, SD = 1.97). Comorbidity burden was not associated with GAF. However, higher depressive (p < 0.0001) and manic (p < 0.0001) symptoms were associated with lower GAF, most strongly among older individuals.
conclusionsFindings suggest an attenuation of BD symptoms in OABD, despite extensive somatic burden. Depressive symptom severity was strongly associated with worse functioning in older individuals, underscoring the need for effective treatments of BD depression in older people. This international collaboration lays a path for the development of a better understanding of aging in BD.
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