Evidence map›Paper›PMID 34314445›Full record

ArticlePloS one2021

Risk factors for poorer health literacy in patients with liver cirrhosis.

Leonard Kaps, Katharina Hildebrand, Michael Nagel, Maurice Michel, Wolfgang Maximilian Kremer, Max Hilscher, Peter R Galle, Jörn M Schattenberg, Marcus-Alexander Wörns, Christian Labenz

Abstract read
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Reducing the Risk of Overt Hepatic Encephalopathy Recurrence: A Narrative Review.Journal of clinical and translational hepatology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Health disparities in cirrhosis care and liver transplantation.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. How do (false) positively screened patients experience a screening programme for liver cirrhosis or fibrosis in Germany? A qualitative study.Health expectations : an international journal of public participation in health care and health policy · 2023
    Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Leonard KapsDepartment of Internal Medicine I, University Medical Centre of the Johannes Gutenberg-University, Mainz, Germany.ORCID 0000-0002-4782-8003
Katharina HildebrandDepartment of Internal Medicine I, University Medical Centre of the Johannes Gutenberg-University, Mainz, Germany.ORCID 0000-0002-6724-622X
Michael NagelDepartment of Internal Medicine I, University Medical Centre of the Johannes Gutenberg-University, Mainz, Germany.
Maurice MichelDepartment of Internal Medicine I, University Medical Centre of the Johannes Gutenberg-University, Mainz, Germany.
Wolfgang Maximilian KremerDepartment of Internal Medicine I, University Medical Centre of the Johannes Gutenberg-University, Mainz, Germany.
Max HilscherDepartment of Internal Medicine I, University Medical Centre of the Johannes Gutenberg-University, Mainz, Germany.
Peter R GalleDepartment of Internal Medicine I, University Medical Centre of the Johannes Gutenberg-University, Mainz, Germany.
Jörn M SchattenbergDepartment of Internal Medicine I, University Medical Centre of the Johannes Gutenberg-University, Mainz, Germany.ORCID 0000-0002-4224-4703
Marcus-Alexander WörnsDepartment of Internal Medicine I, University Medical Centre of the Johannes Gutenberg-University, Mainz, Germany.
Christian LabenzDepartment of Internal Medicine I, University Medical Centre of the Johannes Gutenberg-University, Mainz, Germany.ORCID 0000-0001-8390-9663

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHealth literacy is a concept that refers to patients' ability to manage their disease and the health system's ability to guarantee access to services. There is evidence that health literacy impacts the health outcomes of patients with chronic diseases, but detailed information on this topic in patients with liver cirrhosis is scarce. It was the aim of this study to identify risk factors for poorer health literacy in patients with liver cirrhosis.

methods89 patients with liver cirrhosis were enrolled in this study and health literacy was measured using the Health Literacy Questionnaire (HLQ). Covert hepatic encephalopathy (CHE) was diagnosed clinically according to the West-Haven Criteria (HE grade 1) and the PHES (minimal HE). Depressive symptoms were assessed using the Hamilton Depression Rating Scale (HDRS). Based on the nine subscales of the HLQ, risk factors for poor health literacy were identified using linear regression models.

resultsNormalized HLQ scores ranged between 65-76%, while appraisal of health information had lowest score (65%) and ability to actively engage with healthcare providers had highest score (76%). Multivariable regression analyses revealed an association of poorer health literacy and liver function as determined by MELD score and complications of liver cirrhosis such as a history of ascites or CHE. Additionally, we identified modifiable or preventable factors such as depressive symptoms, a history of falls, and active smoking as risk factors for poorer health literacy.

conclusionMultiple factors seem to impact on health literacy in patients with liver cirrhosis. Addressing modifiable and preventable factors may improve health literacy.

Indexed as

Health LiteracyAgedFemaleHumansLiver CirrhosisMaleMiddle AgedMultivariate AnalysisRisk FactorsSeverity of Illness IndexSurveys and Questionnaires

Identifiers

PMID34314445
PMCPMC8315548

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.