ArticlePLoS computational biology2021
Perturbations in dynamical models of whole-brain activity dissociate between the level and stability of consciousness.
Article in PLoS computational biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Modeled Long-Term Effects of Psilocybin on Dynamic Activity and Effective Connectivity of Fronto-Striatal-Thalamic Circuits.Human brain mapping · 2026Article
- A multi-frequency whole-brain neural mass model with homeostatic feedback inhibition.PLoS computational biology · 2026Article
- A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Shifts in brain dynamics and drivers of consciousness state transitions.Frontiers in computational neuroscience · 2026Article
- Perturbations of whole-brain model reveal critical areas related to relapse of early psychosis.Network neuroscience (Cambridge, Mass.) · 2026Article
- Disrupted hierarchical organization in disorders of consciousness revealed by fluctuation-dissipation deviations.bioRxiv : the preprint server for biology · 2025Article
- Diversity-sensitive brain clocks linked to biophysical mechanisms in aging and dementia.Nature. Mental health · 2025Article
- A multi-frequency whole-brain neural mass model with homeostatic feedback inhibition.bioRxiv : the preprint server for biology · 2025Article
- Detection of EEG dynamic complex patterns in disorders of consciousness.Communications biology · 2025Article
- Modelling low-dimensional interacting brain networks reveals organising principle in human cognition.Network neuroscience (Cambridge, Mass.) · 2025Article
- Adaptive Whole-Brain Dynamics Predictive Method: Relevancy to Mental Disorders.Research (Washington, D.C.) · 2025Article
- Analyzing the brain's dynamic response to targeted stimulation using generative modeling.Network neuroscience (Cambridge, Mass.) · 2025Review
- Whole brain modelling for simulating pharmacological interventions on patients with disorders of consciousness.Communications biology · 2024Article
- Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole-brain modeling.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Biophysical models applied to dementia patients reveal links between geographical origin, gender, disease duration, and loss of neural inhibition.Alzheimer's research & therapy · 2024Article
- The Hopf whole-brain model and its linear approximation.Scientific reports · 2024Article
- Neural mass modeling for the masses: Democratizing access to whole-brain biophysical modeling with FastDMF.Network neuroscience (Cambridge, Mass.) · 2024Article
- Brain state identification and neuromodulation to promote recovery of consciousness.Brain communications · 2024Review
- The nature of consciousness in anaesthesia.BJA open · 2023Review
- A low dimensional embedding of brain dynamics enhances diagnostic accuracy and behavioral prediction in stroke.Scientific reports · 2023Article
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Authors and funding
15 authors.
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Abstract
Consciousness transiently fades away during deep sleep, more stably under anesthesia, and sometimes permanently due to brain injury. The development of an index to quantify the level of consciousness across these different states is regarded as a key problem both in basic and clinical neuroscience. We argue that this problem is ill-defined since such an index would not exhaust all the relevant information about a given state of consciousness. While the level of consciousness can be taken to describe the actual brain state, a complete characterization should also include its potential behavior against external perturbations. We developed and analyzed whole-brain computational models to show that the stability of conscious states provides information complementary to their similarity to conscious wakefulness. Our work leads to a novel methodological framework to sort out different brain states by their stability and reversibility, and illustrates its usefulness to dissociate between physiological (sleep), pathological (brain-injured patients), and pharmacologically-induced (anesthesia) loss of consciousness.
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