Evidence map›Paper›PMID 34314090›Full record

ArticleEMBO reports2021

Quorum sensing governs a transmissive Legionella subpopulation at the pathogen vacuole periphery.

Bianca Striednig, Ulrike Lanner, Selina Niggli, Ana Katic, Simone Vormittag, Sabrina Brülisauer, Ramon Hochstrasser, Andres Kaech, Amanda Welin, Antje Flieger and 4 more

Open access · greenAbstract read
In one paragraph

Article in EMBO reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Small molecule communication ofMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  5. Review
  6. Review
  7. Article
  8. Ecology ofBiofilm · 2024
    Review
  9. Article
  10. Review
  11. Article
  12. Intracellular persister: A stealth agent recalcitrant to antibiotics.Frontiers in cellular and infection microbiology · 2023
    Review
  13. Review
  14. Article
  15. TheApplied and environmental microbiology · 2022
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Bianca StriednigInstitute of Medical Microbiology, University of Zürich, Zürich, Switzerland.ORCID 0000-0001-7575-8965
Ulrike LannerProteomics Core Facility, Biozentrum, University of Basel, Basel, Switzerland.
Selina NiggliInstitute of Medical Microbiology, University of Zürich, Zürich, Switzerland.ORCID 0000-0002-1898-4488
Ana KaticInstitute of Medical Microbiology, University of Zürich, Zürich, Switzerland.
Simone VormittagInstitute of Medical Microbiology, University of Zürich, Zürich, Switzerland.
Sabrina BrülisauerInstitute of Medical Microbiology, University of Zürich, Zürich, Switzerland.
Ramon HochstrasserInstitute of Medical Microbiology, University of Zürich, Zürich, Switzerland.
Andres KaechCenter for Microscopy and Image Analysis, University of Zürich, Zürich, Switzerland.
Amanda WelinDivision of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Antje FliegerDivision of Enteropathogenic Bacteria and Legionella, Robert Koch Institute, Wernigerode, Germany.
Urs ZieglerCenter for Microscopy and Image Analysis, University of Zürich, Zürich, Switzerland.ORCID 0000-0001-7860-1867
Alexander SchmidtProteomics Core Facility, Biozentrum, University of Basel, Basel, Switzerland.ORCID 0000-0002-3149-2381
Hubert HilbiInstitute of Medical Microbiology, University of Zürich, Zürich, Switzerland.ORCID 0000-0002-5462-9301
Nicolas PersonnicInstitute of Medical Microbiology, University of Zürich, Zürich, Switzerland.ORCID 0000-0003-4180-8260
University of Zurich · CHUniversity of Basel · CHLinköping University · SERobert Koch Institute · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Gram-negative bacterium Legionella pneumophila is the causative agent of Legionnaires' disease and replicates in amoebae and macrophages within a distinct compartment, the Legionella-containing vacuole (LCV). The facultative intracellular pathogen switches between a replicative, non-virulent and a non-replicating, virulent/transmissive phase. Here, we show on a single-cell level that at late stages of infection, individual motile (P

Indexed as

LegionellaLegionella pneumophilaLegionnaires' DiseaseBacterial ProteinsHumansQuorum SensingVacuolesBacterial Proteinsflagellumpathogen vacuolephenotypic heterogeneityproteomequorum sensing

Identifiers

PMID34314090
PMCPMC8419707
OpenAlexW3186586377

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.